Publication

Building the epigenetic fortress with PRC2.2

Fides Zenk
2024

Abstract

How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation, which is crucial for gene regulation and lineage specification.

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Building the epigenetic fortress with PRC2.2

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