Publication

Diester-Substituted Aminocyclopropanes: Synthesis and Use in [3+2]-Annulation Reactions

Jérôme Waser, Florian Patrick Marie Daniel De la Barre De Nanteuil, Eloísa Sofía Serrano Robledo
2014
Journal Articles

Abstract

In this Letter, we describe the synthesis of new donor-acceptor substituted cyclopropanes bearing various imido groups and their use in [3+2]-annulation reactions. A sequence of palladium-catalyzed vinylation and rhodium-catalyzed cyclopropanation gave access to the required cyclopropanes in only two steps and high overall yields. The obtained compounds were used successfully in the tin-catalyzed [3+2] annulation with enol ethers to give cyclopentylamine derivatives in 22-95% yield.

Official source

https://infoscience.epfl.ch/entities/publication/65e67b53-0f5b-4594-af30-68e4d5e47da4

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Diester-Substituted Aminocyclopropanes: Synthesis and Use in [3+2]-Annulation Reactions

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