Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity

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Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Whereas HEV infection is typically self‐limiting, rare cases of prolonged cholestasis have been reported. The underlying mechanisms remain unclear, though host genetic variation may contribute. This study aimed to investigate the role of genetic predisposition in HEV‐induced prolonged cholestasis by analysing variants in genes associated with hepatocanalicular transport. We performed a retrospective review of medical records from

L’intelligence artificielle (IA) n’est plus seulement un terme à la mode. Elle devient une partie intégrante de notre vie quotidienne et de notre pratique médicale. Grâce aux avancées majeures des 5 dernières années, l’IA ouvre de nouvelles voies pour aider à améliorer la prévention cardiovasculaire. Cet article en détaille deux aspects : a) aider le patient à gérer ses facteurs de risque cardiovasculaire et son éducation médicale de manière plus autonome et b) aider les cliniciens à améliorer les pratiques

Real-world vaccine effectiveness has increasingly been studied using matching-based approaches, particularly in observational cohort studies that follow the target trial emulation framework. Although matching is appealing in its simplicity, it has important limitations in terms of clarity of the target estimand and the precision with which it is estimated. Moreover, defining causal estimands of vaccine effectiveness requires care, because vaccine uptake often occurs over calendar time when infection dynamic

Hydrurus foetidus is a major primary producer found in glacier-fed streams, which is now threatened by climate change and glacier disappearance. Although it has been reported since 200 years, little is known about this unicellular alga lying at the basis of the food web, which is able to form long filaments (up to 30 cm) and bloom under oligotrophic conditions. In this study, we sequenced, assembled and annotated the nuclear, chloroplast, and mitochondrial genomes of H. foetidus specimen collected in the Sw

Electronic Health Records (EHRs) provide rich longitudinal patient data with potential for predictive modeling, yet remain underutilized due to privacy restrictions on data sharing, irregular sampling with informative missingness, and heterogeneous structure requiring extensive feature engineering. This thesis addresses these challenges through four methodological contributions organized along two complementary axes: privacy-preserving synthetic EHR generation and supervised learning on irregularly sampled

BackgroundSepsis is defined as a dysregulated host response to infection leading to organ dysfunction. It represents a major global health concern, particularly in childhood. The precise underlying pathophysiological mechanisms remain poorly understood.MethodsUsing samples and clinical data from 650 children enrolled in the Swiss Pediatric Sepsis Study, a national multicenter cohort study for culture-proven bacterial sepsis, and from 1395 controls, we explored the human genetic determinants of inter-individ

The virulence of Human Immunodeficiency Virus-1 (HIV-1) is partly determined by viral genetic variation. Finding individual genetic variants affecting virulence is important for our understanding of HIV pathogenesis and evolution of virulence; however, very few have been identified. To this end, within the “Bridging the Evolution and Epidemiology of HIV in Europe” (BEEHIVE) collaboration, we produced whole-genome HIV sequence data for 2294 seroconverters from European countries for a genome-wide association

The biological mechanisms underlying objective and subjective fatigue in post-COVID syndrome remain unclear. This study investigates whether immune responses during the acute phase of SARS-CoV-2 infection predict fatigue dimensions 6–9 months post-infection. We analyzed serum immune markers from 54 hospitalized patients (mean age: 58.69 ± 10.90 yrs; female: 31 %) and assessed their association with chronic fatigue using general linear mixed models. Elevated levels of IL-1RA, IFNγ, TNFα, and monocyte percent

The clinical outcome of SARS-CoV-2 infection spans from asymptomatic viral elimination to lethal COVID-19 pneumonia, which is due to type I interferon (IFN) deficiency in at least 15–20% of cases. We report two unrelated male patients with critical COVID-19 who are heterozygous for rare deleterious variants in RB1CC1, encoding the autophagy-related FIP200 protein. Airway epithelial cells genetically deprived of FIP200 or cell lines expressing the RB1CC1/FIP200 patient variants exhibit elevated SARS-CoV-2 re

Unicorns are private companies with post-money valuations of at least

1 billion, where the valuation is calculated by multiplying the per share price of the most recent financing round with the fully diluted number of common shares (with convertible preferred shares and both issued and unissued stock options counted). Unicorns are a recent phenomenon; venture capitalist Aileen Lee coined the term only in 2013 (Lee 2013). When she introduced it, such

1 billion companies were very rare, hence the name unico

Nanomedicine can offer novel strategies in the fight against antimicrobial resistance. Nano-sized drug carriers can be used to deliver antibiotics to their target to treat infections and some nanomaterials themselves have antimicrobial properties. Here, small amphiphilic gold nanoparticles with mixed ligand surfaces have been investigated for their potential use against bacterial infections in different settings. Owing to their unique surface properties, these nanoparticles are known to directly penetrate c

BACKGROUND Pediatric patients with Diffuse Midline Gliomas (DMG), H3K27M altered have a dismal prognosis and novel therapeutic approaches are urgently needed. Factors that drive development of pediatric DMG are unknown. METHODS To determine the prevalence of germline pathogenic/likely pathogenic variants (P/LPV) in DMG, we assembled an international cohort of 252 patients with germline whole genome or whole exome sequencing data, including diffuse intrinsic pontine glioma (DIPG; n=153), from Australian, Eur

Background The effective reproductive number, Re, is a critical indicator to monitor disease dynamics, inform regional and national policies, and estimate the effectiveness of interventions. It describes the average number of new infections caused by a single infectious person through time. To date, Re estimates are based on clinical data such as observed cases, hospitalizations, and/or deaths. These estimates are temporarily biased when clinical testing or reporting strategies change. Objectives We show th

mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.2.12.1 Spike

Population growth, urbanization and agriculture lead to degradation and loss of natural environment. This has an adverse effect on the diversity of habitats, species and genes and might cause decline in the quality of life of the resident population. In this context and in the densely populated Geneva cross-border area, we study biodiversity dynamics and the effect of the environment on the distribution of genetic variation (URBANGENE project). We use genetic information of three model species (a plant, an

In 2007, FAO initiated the Global plan of action for Farm Animal Genetic Resources (FAnGR) to reduce further loss of genetic diversity in farm animals. One of the key issues mentioned is to identify endangered breeds to support conservation prioritization programs. In this context, the Swiss Federal Office for Agriculture attributed a mandate to explore the feasibility of the implementation of a monitoring concept. The report mentioned the relevance of including the geographic location of the populations mo

Background Corrinoids are an essential cofactor of reductive dehalogenases, the key enzymes of organohalide respiration (OHR). Dehalobacter restrictus is an obligate OHR bacterium (OHRB) able to conserve energy with tetrachloroethene, but is unable to de novo synthesize corrinoids. Genome analysis of D. restrictus strain PER-K23 however revealed the presence of the complete corrinoid biosynthesis pathway. Objectives The aim of the present study is to understand the corrinoid metabolism of D. restrictus stra

The evolution of vertebrate genomes was accompanied by an astounding increase in the complexity of their regulatory modalities. Genetic redundancy resulting from large-scale genome duplications at the base of the chordate tree was repeatedly exploited by the functional redeployment of paralogous genes via innovations in their regulatory circuits. As a paradigm of such regulatory evolution, we have extensively studied those control mechanisms at work in-cis over vertebrate Hox gene clusters. Here, we review

We have characterized sequences expressed in Chinese hamster ovary (CHO) cells which are related to the intracisternal A-particle (IAP) genes of mice and Syrian hamsters. Several cDNA clones homologous to Syrian hamster IAP probes have been isolated and used to evaluate the abundance and expression of these retroviruslike sequences. DNA blot analysis with homologous Chinese hamster IAP probes revealed that IAP-related sequences are present in CHO cell DNA at moderately repetitive levels (approximately 300 c

Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity

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Prolonged Intrahepatic Cholestasis After Acute Hepatitis E Infection: A Case Series and Genetic Analysis

Comment l’intelligence artificielle peut-elle améliorer la prévention cardiovasculaire ?

Target trial emulation without matching: a more efficient approach for evaluating vaccine effectiveness using observational data

Exploring the genome and ecology of Hydrurus foetidus - the dominant alga in glacier-fed streams

Deep Learning Foundations for Irregular Electronic Health Record Time Series: Synthesis, Feature Learning, and Irregular-Time Supervised Modeling

Genome-wide association study of pediatric bacteremia and sepsis

The genetic architecture of HIV-1 virulence

Inflammatory predictors of Post-COVID fatigue

Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

Unicorns

Antimicrobial applications of amphiphilic gold nanoparticles for antibiotic delivery

DIPG-76. PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMA DEMONSTRATE AN UNEXPECTED PREVALENCE OF GERMLINE VARIANTS IN HOMOLOGOUS RECOMBINATION GENES

Wastewater-Based Estimation of the Effective Reproductive Number of SARS-CoV-2

mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.2.12.1 Spike

Biodiversity dynamics and the effect of urban environment on the distribution of genetic variation in the Geneva cross-border area

Data integration, GIS and multi-criteria decision making for the monitoring of livestock genomic resources

Corrinoid auxotrophy in the obligate organohalide-respiring Dehalobacter restrictus strain PER-K23

A genetic approach to the transcriptional regulation of hox gene clusters

Presence and transcription of intracisternal A-particle-related sequences in CHO cells