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During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key component of a regulatory complex that activates the transcription of genes required for centriole formation.
Didier Trono, Evaristo José Planet Letschert, Julien Léonard Duc, Alexandre Coudray, Julien Paul André Pontis, Cyril David Son-Tuyên Pulver, Raphaël Gérard Théodore Michel Marie de Deloÿe et Fourcade de Fondeville, Delphine Yvette L Grun, Shaoline Sheppard