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Optical photothermal infrared spectroscopy sensor including an infrared light source for providing infrared light for illuminating a sample and for absorption by a molecule of the sample, a visible light source for providing light for probing the sample following illumination and absorption of the infrared light by the molecule, a photodetector for detecting the probe light provided from the sample following illumination and absorption of the infrared light by the molecule; and at least one plasmonic metasurface device for contacting and supporting the sample, wherein the at least one plasmonic metasurface device includes at least one metasurface comprising a plurality of nano-slits configured to enhance infrared light absorption by the at least one biomolecule or molecule of the at least one sample.