Publication

gem-Difluorocyclopropanes: an improved method for their preparation

Manfred Schlosser
1990
Journal Articles

Abstract

By treatment with Br2CF2 and Ph3P, 4 unfunctionalized olefins, 4 enol ethers and 1 bis-enol ether were converted to gem-difluorocyclopropanes. Thus, RCH:CHOPr (R = H, Me) gave difluorocyclopanes I in 73 and 83% yield, resp. The yields were considerably increased and isomerizations at the double bonds were avoided if the reactions were carried out in the presence of a macrocyclic polyether such as 18-crown-6 and a moderate excess of reagents. [on SciFinder (R)]

Official source

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Manfred Schlosser
1990
Journal Articles

Abstract

Official source

Related concepts (32)

Wittig reagents

In organic chemistry, Wittig reagents are organophosphorus compounds of the formula R3P=CHR', where R is usually phenyl. They are used to convert ketones and aldehydes to alkenes: Because they typically hydrolyze and oxidize readily, Wittig reagents are prepared using air-free techniques. They are typically generated and used in situ. THF is a typical solvent. Some are sufficiently stable to be sold commercially. Wittig reagents are usually prepared from a phosphonium salt, which is in turn prepared by the quaternization of triphenylphosphine with an alkyl halide.

Wastewater treatment

Wastewater treatment is a process which removes and eliminates contaminants from wastewater and converts this into an effluent that can be returned to the water cycle. Once returned to the water cycle, the effluent creates an acceptable impact on the environment or is reused for various purposes (called water reclamation). The treatment process takes place in a wastewater treatment plant. There are several kinds of wastewater which are treated at the appropriate type of wastewater treatment plant.

Grignard reagent

A Grignard reagent or Grignard compound is a chemical compound with the general formula , where X is a halogen and R is an organic group, normally an alkyl or aryl. Two typical examples are methylmagnesium chloride and phenylmagnesium bromide . They are a subclass of the organomagnesium compounds. Grignard compounds are popular reagents in organic synthesis for creating new carbon-carbon bonds. For example, when reacted with another halogenated compound in the presence of a suitable catalyst, they typically yield and the magnesium halide as a byproduct; and the latter is insoluble in the solvents normally used.

Related publications (2)

gem-Difluorocyclopropanes: an improved method for their preparation

Chat with Graph Search

Design of novel enzyme-catalyzed reactions linked to protein sequences for finding enzyme engineering targets

The two-fold reaction benchmark applied to the copper catalyzed assembling of 1,w-difunctional hydrocarbon chains