Publication

Functional molecular thin films: topological templates for the chemoselective ligation of antigenic peptides to self-assembled monolayers

Horst Arthur Vogel, Kirsten Leufgen
1999
Journal Articles

Abstract

Chem. ligation methods in combination with regioselective addressable templates have allowed the prepn. of well defined complex monomol. films tethered to gold surfaces. The supramol. monolayers exposed artificial recognition sites, here for monoclonal antibodies. SPR, FTIR spectroscopies, and TOF-SIMS were ideally suited surface sensitive techniques to enable the essential control of the individual reaction steps. The concept presented here for the functionalization of gold surfaces may be easily applied to other supporting materials, and is not limited to peptides, but may equally extend to proteins or nucleic acids. This approach may be extended to the construction of multifunctional surfaces with potential in bio-analytics. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/6060b028-cf5b-4d9e-b0ff-20092b638af2

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Horst Arthur Vogel, Kirsten Leufgen
1999
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/6060b028-cf5b-4d9e-b0ff-20092b638af2

About this result

Related concepts (32)

Antigen

In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. Antigens can be proteins, peptides (amino acid chains), polysaccharides (chains of simple sugars), lipids, or nucleic acids. Antigens exist on normal cells, cancer cells, parasites, viruses, fungi, and bacteria. Antigens are recognized by antigen receptors, including antibodies and T-cell receptors.

Antigen presentation

Antigen presentation is a vital immune process that is essential for T cell immune response triggering. Because T cells recognize only fragmented antigens displayed on cell surfaces, antigen processing must occur before the antigen fragment, now bound to the major histocompatibility complex (MHC), is transported to the surface of the cell, a process known as presentation, where it can be recognized by a T-cell receptor. If there has been an infection with viruses or bacteria, the cell will present an endogenous or exogenous peptide fragment derived from the antigen by MHC molecules.

Antigen processing

Antigen processing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes. It is considered to be a stage of antigen presentation pathways. This process involves two distinct pathways for processing of antigens from an organism's own (self) proteins or intracellular pathogens (e.g. viruses), or from phagocytosed pathogens (e.g. bacteria); subsequent presentation of these antigens on class I or class II major histocompatibility complex (MHC) molecules is dependent on which pathway is used.

Related publications (1)

Functional molecular thin films: topological templates for the chemoselective ligation of antigenic peptides to self-assembled monolayers

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Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene