Publications related to PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer

Related publications (15)

Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING

Daniel Constam, Giovanna Ambrosini, Nicolas Jean Philippe Guex, Christian Iseli, Katarina Pinjusic, Olga Egorova

The transforming growth factor-beta (TGF-beta) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly imped ...

Frontiers Media Sa2024

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Ali Ghasemi

Dendritic cells (DCs) are specialized myeloid cells with the ability to uptake, process, and present antigens to T lymphocytes. They also generate cytokine and chemokine gradients that regulate immune cell trafficking, activation, and function. Monocyte-de ...

EPFL2024

Lymph node microstructure imaging using diffusion MRI: From simulations to acquisitions

Rémy Marc M Gardier

Early tumor detection is crucial for maximizing treatment effectiveness and the chances of recovery. Currently, medical doctors rely on the combination of non-specific (X-ray, MRI, CT) or invasive (PET) imaging modalities and the analysis of tissue samples ...

EPFL2024

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Irina Sinenko

Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

EPFL2023

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Freddy Radtke, Romain Hamelin, Nadine Fournier, Linlin Cao, Florence Armand, Maria Pavlou

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitati ...

2023

Highly effective adoptive t cell therapy

Li Tang, Yugang Guo, Bing Feng

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions ...

2023

Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

Michel Aguet, Andreas Eduard Moor

Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need f ...

CELL PRESS2021

Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration

Gianrocco Lazzari

The management of advanced ovarian cancer is challenging due to the high frequency of recurrence, often associated with the development of resistance to platinum-based chemotherapy. Molecular analyses revealed the complexity of ovarian cancer with particul ...

SPANDIDOS PUBL LTD2019

Gender medicine and oncology: report and consensus of an ESMO workshop

Jacques Fellay

Background: The importance of sex and gender as modulators of disease biology and treatment outcomes is well known in other disciplines of medicine, such as cardiology, but remains an undervalued issue in oncology. Considering the increasing evidence for t ...

OXFORD UNIV PRESS2019

Platinum sensitivity of ovarian cancer cells does not influence their ability to induce M2-type macrophage polarization

Mei-Wen Peng

ProblemDevelopment of platinum resistance in ovarian cancer is mediated by both cancer cells and tumor microenvironment. Activation of epithelial-mesenchymal transition program in cancer cells may lead to enrichment for resistant clones. These processes ca ...

WILEY2018

RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma

Etienne Meylan, Nadine Fournier, Julien Robert Rémi Faget, Caroline Anne-Lyse Contat

INTRODUCTION: NSCLC is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and might represent a new treatment strategy. M ...

2018

Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology

Francesco Stellacci, Zhi Luo, Yanfei Zhao, Jing Hou

Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simples ...

Nature Publishing Group2018

Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1

Paul Joseph Dyson

Background: The RAPTA-EA1 complex [ruthenium(II)-arene 1,3,5-triaza-7-phosphaadamantane (pta) complex with an arene-tethered ethacrynic acid ligand] has been reported to overcome drug resistance that developed due to the current use of platinum-based treat ...

Bentham Science Publ Ltd2017

Electrostatic spray ionization from 384-well microtiter plates for mass spectrometry analysis based enzyme assay and drug metabolism screening

Hubert Girault, Liang Qiao, Tzu-En Lin, Elena Tobolkina, Xiaoqin Zhong

We have realized the direct ionization of samples from wells of microtiter plates under atmospheric conditions for mass spectrometry analysis without any liquid delivery system or any additional interface. The microtiter plate is a commercially available 3 ...

American Chemical Society2017

Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer

Maria Soler Aznar

Colorectal cancer is treatable and curable when detected at early stages. However there is a lack of less invasive and more specific screening and diagnosis methods which would facilitate its prompt identification. Blood circulating autoantibodies which ar ...

Elsevier Science Bv2016