A Novel Microfluidic System for Capacitive Detection Via Magnetophoretic Separation of Malaria-Infected Red Blood Cells

Malaria continues to pose a significant global health challenge, with substantial impediments arising from the need for more reliable, effective, and economically viable diagnostic tools, particularly for early detection. This research introduces a novel microfluidic device designed for malaria-diagnostics through the detection of hemozoin (Hz), a prevalent biomarker for the disease. Our methodology involves the collection of a minimal blood sample, which is subsequently processed through a microfluidic system. This system exploits the paramagnetic properties of Hz to isolate infected blood cells using magnetophoretic separation. The detection process employs a relative capacitive measurement technique capable of quantifying Hz concentrations ranging from 417 fM to 17 pM, facilitating and enhancing malaria diagnosis. Simulations results confirm the efficacy of our device in providing a rapid, cost-effective, and readily producible diagnostic solution. This research demonstrates the potential of integrating advanced microfluidic technology and sensitive detection systems into a compact, portable unit, offering significant improvements over existing malaria diagnostic tools.