Publication

Zinc uptake by brain cells: 'Surface' versus 'bulk'

Giorgio Margaritondo
1996
Journal Articles

Abstract

The uptake of zinc by cerebellar rat cultures upon exposure to ZnCl2 solutions was comparatively investigated using two well known condensed matter physics techniques: synchrotron photoelectron spectromicroscopy and inductively coupled plasma atomic emission spectroscopy. The objective was to apply a strategy-well known in surface physics-to distinguish between 'surface' and 'bulk' phenomena. The results clearly demonstrate that exposure significantly enhances the bulk (cell cytoplasm) Zn concentration with respect to the physiological level, whereas the effect on the surface (cell membrane) is negligible.

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https://infoscience.epfl.ch/entities/publication/5d32c3ef-88b4-4e5d-8af8-3942b461a2c9

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Giorgio Margaritondo
1996
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/5d32c3ef-88b4-4e5d-8af8-3942b461a2c9

About this result

Related concepts (32)

Zinc

Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodic table. In some respects, zinc is chemically similar to magnesium: both elements exhibit only one normal oxidation state (+2), and the Zn2+ and Mg2+ ions are of similar size. Zinc is the 24th most abundant element in Earth's crust and has five stable isotopes.

Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures.

Zinc chloride

Zinc chloride is the name of inorganic chemical compounds with the formula . It forms hydrates. Zinc chloride, anhydrous and its hydrates are colorless or white crystalline solids, and are highly soluble in water. Five hydrates of zinc chloride are known, as well as four forms of anhydrous zinc chloride. This salt is hygroscopic and even deliquescent. Zinc chloride finds wide application in textile processing, metallurgical fluxes, and chemical synthesis. No mineral with this chemical composition is known aside from the very rare mineral simonkolleite, .

Related publications (12)

Zinc uptake by brain cells: 'Surface' versus 'bulk'

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