Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

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Bruton's tyrosine kinase (Btk) is critical for B-cell maturation and activation. Btk loss-of-function mutations cause human X-linked agammaglobulinemia (XLA). In contrast, Btk signaling sustains growth of several B-cell neoplasms which may be treated with ...

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Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

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