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The Middle East-North Africa (MENA) is a major climate change hotspot region where temperatures have risen faster than the global average over recent decades. Global climate warming levels of 2 C, 3 C. and 4 C have been bias adjusted and downscaled using a regional climate model, indicating escalating heat risks in MENA. With 2 C global warming, the Arabian Gulf area will start experiencing life-threatening humid-heat conditions with wet-bulb temperatures (TWs) exceeding 30 C, partially approaching 35 C, the limit of human survivability. Extreme 1-in-50-year heat events under current conditions in the MENA will likely recur every few years. At 3 C, approximately 50% of MENA's population is projected to face dangerous heat conditions (> 40 C) and multiple areas have TWs >30 C, up to >35 C. At 4 C global warming, more than 600 million people in MENA will be exposed to dangerous heat conditions, including about 60 million facing extremely dangerous temperatures above 51 C. Over 30 million people are projected to experience wet-bulb temperatures exceeding 30 C, with the most extreme conditions expected in the Gulf region, the Nile Delta, and the southeastern Mediterranean coast. Considering rapid global and accelerating MENA warming, these findings underscore the urgency of implementing climate change adaptation measures. KEYWORDS Climate warming; humid-heat extremes; Weather Research and Forecasting model (WRF); projections; MENA-CORDEX CRITICAL INSIGHTS SUMMARY Mapping tomorrow's heat: higher-resolution insights into climate extremes and human risk