Publication

Characterization of monoclonal IgA production and activity in hollow-fiber and fluidized-bed reactors

Urs von Stockar, Ian William Marison
1996
Book Chapters

Abstract

An IgA-producing hybridoma cell line has been grown in two hollow-fiber reactors and one fluidized-bed reactor, using a serum-contg. medium and a protein-free medium. Comparisons have been made on the basis of product quantity (total IgA) and quality (active fraction, mol. wt. pattern). In hollow fiber reactors, IgA was produced at very high concns. but the fraction of active material was relatively low. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/58ed36dc-9fe4-469d-b4df-102ee86489f6

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Urs von Stockar, Ian William Marison
1996
Book Chapters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/58ed36dc-9fe4-469d-b4df-102ee86489f6

About this result

Related concepts (16)

Fluidized bed

A fluidized bed is a physical phenomenon that occurs when a solid particulate substance (usually present in a holding vessel) is under the right conditions so that it behaves like a fluid. The usual way to achieve a fluidized bed is to pump pressurized fluid into the particles. The resulting medium then has many properties and characteristics of normal fluids, such as the ability to free-flow under gravity, or to be pumped using fluid technologies. The resulting phenomenon is called fluidization.

Plasma cell dyscrasias

Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof.

Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision.