Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

How the 'what', 'where', and 'when' of past experiences are stored in episodic memories and retrieved for suitable decisions remains unclear. In an effort to address these questions, the authors present computational models of neural networks that behave l ...

The recollection of sensory information and subjective experience related to a personal past event depends on our episodic memory (EM). At the neural level, EM retrieval is linked with the reinstatement of hippocampal activity thought to recollect the sens ...

Time-lapse light microscopy combined with in vitro neuronal cultures has provided a significant contribution to the field of Developmental Neuroscience. The establishment of the neuronal polarity, i.e., formation of axons and dendrites, key structures resp ...

Traumatic events generate some of the most enduring memories, yet little is known about how long-lasting fear memories can be attenuated. In this review, we collect the surprisingly sparse evidence on remote fear memory attenuation from both animal and hum ...

Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...

The selective and sensitive sensing of neurochemicals is essential to decipher in-brain chemistry underlying brain pathophysiology. The recent development of flexible and multifunctional polymer-based fibers has been shown useful in recording and modulatin ...

Glutamate is a principal neurotransmitter used extensively by the nervous systems of all vertebrate and invertebrate animals. It is primarily an excitatory neurotransmitter that has been implicated in nervous system development, as well as a myriad of brai ...

Empirical evidence shows that memories that are frequently revisited are easy to recall, and that familiar items involve larger hippocampal representations than less familiar ones. In line with these observations, here we develop a modelling approach to pr ...

Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...

A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhan ...

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...

Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Chat with Graph Search

Computational models of episodic-like memory in food-caching birds

Bodily self-consciousness as a framework to link sensory information and self-related components of episodic memory: behavioral, neuroimaging, and clinical evidence

Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities

Face your fears: attenuating remote fear memories by reconsolidation-updating

Cortical cell assemblies and their underlying connectivity: an in silico study

The Development of Aptamer-Coupled Microelectrode Fiber Sensors (apta-?FS) for Highly Selective Neurochemical Sensing

A conditional glutamatergic synaptic vesicle marker for Drosophila

A dynamic attractor network model of memory formation, reinforcement and forgetting

Lactate supply overtakes glucose when neural computational and cognitive loads scale up

Prefrontal engrams of long-term fear memory perpetuate pain perception

Epigenetic plasticity as a signature for memory allocation

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning