Photopolymerization device for minimally invasive implants: application to nucleus pulposus replacement

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This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

In recent years, there has been a surge of interest in predicting computed activation barriers, to enable the acceleration of the automated exploration of reaction networks. Consequently, various predictive approaches have emerged, ranging from graph-based ...

Background In contact sports, an impact on the jaw can generate destructive stress on the tooth-bone system. Mouthguards can be beneficial in reducing the injury risk by changing the dynamics of the trauma. The material properties of mouthguards and their ...

The collimation system of the Future Circular Collider, operating with leptons (FCC-ee), must protect not only the experiments against backgrounds, but also the machine itself from beam losses. With a 17.8 MJ stored energy of the electron and positron beam ...

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Neurodegenerative and neuroinflammatory disorders often involve complex pathophysiological mechanisms that are â to this date â only partially understood. A more comprehensive understanding of those microstructural processes and their characterization ...

The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patte ...

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

The application of microfluidics in the field of surface-based assays and more specifically, the spatial molecular profiling of tumor tissues has gained a lot of interest, especially with the increased interest in personalized medicine and targeted therapy ...

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Hydrogels are among the first materials expressly designed for their use in biomedicine. However, state-of-the-art applications of hydrogels are severely limited because they are typically either too soft or too brittle such that they cannot bear significa ...

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Absorption in amine solutions is a well-established advanced technology for CO2 capture. However, the fundamental aspects of the chemical reactions occurring in solution still appear to be unclear. Our previous investigation of aqueous monoethanolamine (ME ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

Reaction optimization is challenging and traditionally delegated to domain experts who iteratively pro-pose increasingly optimal experiments. Problematically, the reaction landscape is complex and often requires hundreds of experiments to reach convergence ...

The backscattering process in hollow core fibres shows a large similarity with Rayleigh scattering, offering the potential to be exploited for distributed sensing. A classical Φ-OTDR implementation is used to observe the backscattering signal from the surf ...

Semiconductor materials have given rise to today's digital technology and consumer electronics. Widespread adoption is closely linked to the ability to process and integrate them in devices at scale. Where flexibility and large surfaces are required, such ...

Understanding how biological matter takes its shape is instrumental to biology, bioengineering, medicine, and bioinspired engineering. Gaining information on the principles of morphogenesis could enable clinicians to correct developmental abnormalities, ev ...

Micrometer sized capsules are often used as single entities for the encapsulation and release of active ingredients, for example in food, cosmetics, and drug delivery. Important parameters that determine the stability of capsules and the release of reagent ...

The complex mechanics of porous and granular media play a significant role in various industrial processes and natural phenomena. As an example, understanding the mechanics of how failure occurs, localizes and propagates in porous brittle solids under vari ...

Photopolymerization device for minimally invasive implants: application to nucleus pulposus replacement

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Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Benchmarking machine-readable vectors of chemical reactions on computed activation barriers

Design of Customized Mouthguards with Superior Protection Using Digital-Based Technologies and Impact Tests

Collimation simulations for the FCC-ee

Parametric Wavelength Conversion in Waveguiding Structures: Efficiency, Bandwidth and Polarization

Development and clinical validation of computational imaging biomarkers for neurodegenerative diseases

Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Development of next-generation microfluidic systems for enhanced, faster, and cost-effective immunoassays for tissue diagnostics - Ac electrothermal flow & Acoustofluidics

Bringing casting to microfabrication: processing and deformation of microcastings

Controlling the Microstructure and Composition of 3D Printed Soft Load-Bearing Hydrogels

Inferring free-energy barriers and kinetic rates from molecular dynamics via underdamped Langevin models

CO2 Capture and Release in Amine Solutions: To What Extent Can Molecular Simulations Help Understand the Trends?

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Bayesian Optimization for Chemical Reactions

Study on the possibility of Φ-OTDR sensing in hollow-core fibres

Semiconductor-based device architectures in multimaterial fibers

Development of a Robotic Microsurgeon for Embryonic Research

From Surfactants to Viscoelastic Capsules

Modeling the mechanics and rheology of porous and granular media: an elastoplastic continuum approach