Engineering Neuron Models : from Ion Channels to Electrical Behavior

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Long-range projections are the structural basis for inter-areal interactions across a cortical hierarchy. These connections are classified based on their laminar termination profiles into feed-forward, when they connect a lower-order to a higher-order area ...

The ability of the brain to produce adaptive and dexterous movements relies on the seamless integration of sensory feedback into motor commands. Despite significant advances in motor neuroscience, critical gaps persist in understanding how proprioceptive a ...

The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Focusing on the uniquely evolved human cortical layers 2 and 3, we computationally reconstruct the cortical architecture for ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Proprioception tells the brain the state of the body based on distributed sensors in the body. However, the principles that govern proprioceptive processing from those distributed sensors are poorly understood. Here, we employ a task-driven neural network ...

Neural decoding of the visual system is a subject of research interest, both to understand how the visual system works and to be able to use this knowledge in areas, such as computer vision or brain-computer interfaces. Spike-based decoding is often used, ...

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

Human babies have a natural desire to interact with new toys and objects, through which they learn how the world around them works, e.g., that glass shatters when dropped, but a rubber ball does not. When their predictions are proven incorrect, such as whe ...

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity has been di ...

This thesis investigates the growing field of biological nanopores, their applications in molecular sensing and their non-linear ion transport. Biological nanopores, naturally evolved to regulate membrane transport, have been adapted for use in biotechnolo ...

Transformer models such as GPT generate human-like language and are predictive of human brain responses to language. Here, using functional-MRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model can predict t ...

In light of the challenges posed by climate change and the goals of the Paris Agreement, electricity generation is shifting to a more renewable and decentralized pattern, while the operation of systems like buildings is increasingly electrified. This calls ...

Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

This article summarizes the recent advancements in the design, fabrication, and control of microrobotic devices for the diagnosis and treatment of brain disorders. With a focus on diverse actuation methods, we discuss how advancements in materials science ...

Anthropogenic modification of natural landscapes to urban environments impacts land-atmosphere interactions in the boundary layer. Ample research has demonstrated the effect of such landscape transitions on development of the urban heat island (UHI), but c ...

Motivation is a multifaceted phenomenon that we explore within the framework of decision-making. Through this cognitive process, actions are directed towards specific goals by performing a trade-off between the cost and benefit of an action. The dorsomedia ...

Engineering Neuron Models : from Ion Channels to Electrical Behavior

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Principles of inter-areal interactions in cortical sensory processing

Reverse engineering primate sensorimotor control with machine learning

Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks

White adipose tissue distribution and amount are associated with increased white matter connectivity

Task-driven neural network models predict neural dynamics of proprioception: Neural network model weights

Predicting Visual Stimuli From Cortical Response Recorded With Wide-Field Imaging in a Mouse

Subcortical correlates of consciousness with human single neuron recordings

Seeking the new, learning from the unexpected: Computational models of surprise and novelty in the brain

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Exploring ion and analyte transport in beta-barrel forming biological nanopores

Driving and suppressing the human language network using large language models

Quantifying the Unknown: Data-Driven Approaches and Applications in Energy Systems

Structural heterogeneity of the ion and lipid channel TMEM16F

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Small-scale robotic devices for medical interventions in the brain

Urban boundary-layer flows in complex terrain: Dynamic interactions during a hot and dry summer season in Phoenix, Arizona

Neurobiological and metabolic basis of motivation and effort-based decision-making - A human 1H-MRS, fMRI and machine learning study