Publications related to In-vivo performance of high-density collagen gel tubes for urethral regeneration in a rabbit model

Related publications (36)

An artificial urinary sphincter based on dielectric elastomer technology

Sloan Zammouri, Yves Perriard, Yoan René Cyrille Civet, Stefania Maria Aliki Konstantinidi, Amine Benouhiba, Quentin Philippe Mario De Menech

Urinary incontinence (UI) is prevalent and distressing medical condition affecting millions of patients worldwide. Current treatment options for severe cases often involve surgical intervention, such as the implantation of an artificial urinary sphincter ( ...

Society of Photo-Optical Instrumentation Engineers (SPIE)2024

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

Dominique Pioletti, Lee Ann Laurent-Applegate, Peyman Karami

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage r ...

MDPI2024

Mechanical Characterisation of Porcine Urethra: Non Linear Constitutive Models and Experimental Approach

Yves Perriard, Yoan René Cyrille Civet, Thomas Guillaume Martinez, Stefania Maria Aliki Konstantinidi, Amine Benouhiba, Quentin Philippe Mario De Menech

Low urinary tract dysfunctions and symptoms (LUTS) and Urinary incontinence (UI) in particular is a medical condition that affects millions of people worldwide. One of the most promising long term treatments for this condition is the use of an artificial u ...

IEEE2023

Decoding bladder state from pudendal intraneural signals in pigs

Silvestro Micera, Stéphanie Lacour, Ivo Strauss, Valentina Marie Paggi, Leonardo Pollina

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the ...

2023

Active microrheology in corrugated channels: Comparison of thermal and colloidal baths

Ignacio Pagonabarraga Mora

Hypothesis: The dynamics of colloidal suspension confined within porous materials strongly differs from that in the bulk. In particular, within porous materials, the presence of boundaries with complex shapes entangles the longitudinal and transverse degre ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

Bart Deplancke, Vincent Roland Julien Gardeux, Fabrice David, Wouter Jozef L Saelens

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed ti ...

American Association for the Advancement of Science2022

Fiber density of collagen grafts impacts rabbit urethral regeneration

Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar

There is a need for efficient and “off-the-shelf” grafts in urethral reconstructive surgery. Currently available surgical techniques require harvesting of grafts from autologous sites, with increased risk of surgical complications and added patient discomf ...

Nature Research2018

Novel Concept Enabling an Old Idea: A Flexible Electrode Array to Treat Neurogenic Erectile Dysfunction

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva, Mikaël Nils Sturny

Introduction: Many studies have shown that electrostimulation of the cavernosal nerve can induce and maintain penile erection. Based on these discoveries, neurostimulation to activate the erectile response has been considered a potential solution to treat ...

ELSEVIER SCI LTD2018

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells

Sulagna Mukherjee

Recently, adaptive non-shivering thermogenesis has attracted considerable attention because it can elevate energy expenditure and help treat obesity. Despite the numerous reports related to UCP1-driven thermogenesis, little is known regarding UCP1-independ ...

KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING2022

Engineered acellular collagen scaffold for endogenous cell guidance, a novel approach in urethral regeneration

Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Elif Vardar

The treatment of congenital malformations or injuries of the urethra using existing autologous tissues can be associated with post-operative complications. Using rat-tail collagen, we have engineered an acellular high-density collagen tube. These tubes wer ...

Elsevier Sci Ltd2016

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Elif Vardar

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Johan Auwerx, Davide D'Amico, Pamela Solange Valdés Undurraga, Pénélope Andreux

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

2021

Implant-based three-dimensional superimposition of the growing mandible in a rabbit model

The reliable assessment of craniofacial morphological changes during growth requires invariant regions for image registration. As these regions have not yet been identified in three dimensions, intra-osseous implants are required as fiducial markers for th ...

Oxford Univ Press2016

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

Kunal Sharma

Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...

EPFL2021

Eyewatch, an Innovative Adjustable GDD for the Treatment of Glaucoma - in Vivo Results

Nikolaos Stergiopoulos, André Mermoud, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE: To report the in vivo results of a continuously adjustable glaucoma drainage device (GDD) in glaucoma surgery with rabbits. METHODS: Under general anesthesia, the AGDD was implanted on 12 white New-Zealand rabbits for duration of 6 months. The adj ...

Springer2016

Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration

Elif Vardar

Urological tissue engineering offers alternative solutions for congenital and acquired diseases of the urinary tract, which may require reconstructive surgery. It evolves to overcome complications, which might be encountered after surgery. Therefore, tissu ...

EPFL2015

Geometric optimization of dielectric elastomer electrodes for dynamic applications

Herbert Shea, Bekir Aksoy

Dielectric elastomers are soft actuators, made of an elastomer membrane sandwiched by compliant electrodes. Because of their high energy density and quick response, they are well suited for dynamic applications such as loudspeakers. Thanks to progress in t ...

ELSEVIER SCI LTD2021

Co-regulation of endothelial and myogenic cell fates through intercellular crosstalk in skeletal muscle

Umji Lee

Skeletal muscle is one of the most dynamic organs in the human body, which has a vigorous potential to regenerate and adapt to environmental changes. Depending on environments, skeletal muscle enables essential life activities to survive by controlling mov ...

EPFL2021

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Graham Knott, John McKinney, Neeraj Dhar, Vivek Vijay Thacker, François Signorino-Gelo, Kunal Sharma, Thomas Marie Simonet

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and anti ...

2021