Publications related to Seizure suppression by adenosine-releasing cells is independent of seizure frequency

Ambulatory seizure detection

Purpose of review: To review recent advances in the field of seizure detection in ambulatory patients with epilepsy. Recent findings: Recent studies have shown that wrist or arm wearable sensors, using 3D-accelerometry, electrodermal activity or photopleth ...

2024

Resource-Efficient Continual Learning for Personalized Online Seizure Detection

David Atienza Alonso, Giovanni Ansaloni, Flavio Ponzina, Amirhossein Shahbazinia, José Angel Miranda Calero, Jonathan Dan

Epilepsy, a major neurological disease, requires careful diagnosis and treatment. However, the detection of epileptic seizures remains a significant challenge. Current clinical practice relies on expert analysis of EEG signals, a process that is time-consu ...

IEEE2024

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

EPFL2024

Subcortical correlates of consciousness with human single neuron recordings

Michael Eric Anthony Pereira, Olaf Blanke, Nathan Quentin Faivre, Fosco Bernasconi

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

2024

Hardware Implementation of Digital Signal Processing Algorithms for Programmable Epilepsy Control Systems

Keyvan Farhang Razi

Epilepsy is a common chronic neurological disorder that causes recurring seizures and affects more than 50 million people worldwide. Implantable medical devices (IMDs) are regarded as effective tools to cure patients who suffer from refractory epilepsy. Se ...

EPFL2023

Enhancing Epileptic Seizure Detection with EEG Feature Embeddings

Mahsa Shoaran, Bingzhao Zhu, Arman Zarei

Epilepsy is one of the most prevalent brain disorders that disrupts the lives of millions worldwide. For patients with drug-resistant seizures, there exist implantable devices capable of monitoring neural activity, promptly triggering neurostimulation to r ...

ArXiv2023

Hyperdimensional computing for biosignal monitoring: Applications for epilepsy detection

Una Pale

Hyperdimensional (HD) computing is a novel approach to machine learning inspired by neuroscience, which uses vectors in a hyper-dimensional space to represent data and models. This approach has gained significant interest in recent years with applications ...

EPFL2023

Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

Patric Hagmann, Dimitri Nestor Alice Van De Ville, Maria Giulia Preti

Objective: Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE). ...

ELSEVIER IRELAND LTD2023

Combined use of intraoperative MRI and awake tailored microsurgical resection to respect functional neural networks: preliminary experience

Constantin Tuleasca

INTRODUCTION: The combined use of intraoperative MRI and awake surgery is a tailored microsurgical resection to respect functional neural networks (mainly the language and motor ones). Intraoperative MRI has been classically considered to increase the exte ...

2023

Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury

Carmina Andrea Galvez Solano

Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...

EPFL2023

How I became myself after merging with a computer: Does human-machine symbiosis raise human rights issues?

Marcello Ienca

Novel usages of brain stimulation combined with artificially intelligent (AI) systems promise to address a large range of diseases. These new conjoined technologies, such as brain-computer interfaces (BCI), are increasingly used in experimental and clinica ...

ELSEVIER SCIENCE INC2023

An attention-based deep learning approach for the classification of subjective cognitive decline and mild cognitive impairment using resting-state EEG

Silvestro Micera, Michael Lassi

Objective. This study aims to design and implement the first deep learning (DL) model to classify subjects in the prodromic states of Alzheimer's disease (AD) based on resting-state electroencephalographic (EEG) signals. Approach. EEG recordings of 17 heal ...

IOP Publishing Ltd2023

Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer's Disease continuum?

Silvestro Micera, Michael Lassi

Alzheimer's disease (AD) pathological changes may begin up to decades earlier than the appearance of the first symptoms of cognitive decline. Subjective cognitive decline (SCD) could be the first pre-clinical sign of possible AD, which might be followed by ...

ELSEVIER SCI LTD2023

Personalized seizure signature: An interpretable approach to false alarm reduction for long‐term epileptic seizure detection

David Atienza Alonso, Amir Aminifar, Dionisije Sopic, Tomas Teijeiro Campo

Objective Long-term automatic detection of focal seizures remains one of the major challenges in epilepsy due to the unacceptably high number of false alarms from state-of-the-art methods. Our aim was to investigate to what extent a new patient-specific ap ...

2022

Multi-Centroid Hyperdimensional Computing Approach for Epileptic Seizure Detection

David Atienza Alonso, Una Pale, Tomas Teijeiro Campo

Long-term monitoring of patients with epilepsy presents a challenging problem from the engineering perspective of real-time detection and wearable devices design. It requires new solutions that allow continuous unobstructed monitoring and reliable detectio ...

2022

Exploration of Hyperdimensional Computing Strategies for Enhanced Learning on Epileptic Seizure Detection

David Atienza Alonso, Una Pale, Tomas Teijeiro Campo

Wearable and unobtrusive monitoring and prediction of epileptic seizures has the potential to significantly increase the life quality of patients, but is still an unreached goal due to challenges of real-time detection and wearable devices design. Hyperdim ...

2022

Epileptic Seizure Detection With Patient-Specific Feature and Channel Selection for Low-power Applications

Alexandre Schmid, Keyvan Farhang Razi

An accurate epileptic seizure detector using intracranial electroencephalography (iEEG) recordings, suitable for low-power wearable/implantable applications, is presented. Eleven time-domain features with low hardware complexity are employed in the feature ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Approximate Zero-Crossing: A new interpretable, highly discriminative and low-complexity feature for EEG and iEEG seizure detection

David Atienza Alonso, Una Pale, Renato Zanetti, Tomas Teijeiro Campo

Objective: Long-term monitoring of people with epilepsy based on electroencephalography (EEG) and intracranial EEG (iEEG) has the potential to deliver key clinical information for personalised epilepsy treatment. More specifically, in outpatient settings, ...

2022

Disruption of layer-specific visual processing in a model of focal neocortical epilepsy

Silvestro Micera, Matteo Vissani

The epileptic brain is the result of a sequence of events transforming normal neuronal populations into hyperexcitable networks supporting recurrent seizure generation. These modifications are known to induce fundamental alterations of circuit function and ...

OXFORD UNIV PRESS INC2022

Hardware-Friendly Random Forest Classification of iEEG Signals for Implantable Seizure Detection

Alexandre Schmid, Keyvan Farhang Razi

Early and accurate detection of epileptic seizures is an extremely important therapeutic goal due to the severity of complications it can prevent. To this end, a low-power machine learning-based seizure detection implemented on an FPGA is proposed in this ...

IEEE2022