Publication

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Johan Auwerx, Carlos Canto Alvarez
2011
Reviews

Abstract

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.

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Interference between PARPs and SIRT1: a novel approach to healthy ageing?

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