Publication

Virology: Poxins Soothe the STING

Andrea Ablasser, Alexiane Clara Decout
2019
Journal Articles

Abstract

The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham et al. identified poxins as 2', 3'-cGAMP-specific nucleases allowing immune evasion by viruses.

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Virology: Poxins Soothe the STING

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