Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections

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Realand imaginary -time quantum state evolutions are crucial in physics and chemistry for exploring quantum dynamics, preparing ground states, and computing thermodynamic observables. On near -term devices, variational quantum time evolution is a promising ...

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Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular miRNAs in ce ...

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Populations of human cytomegalovirus (HCMV), a large DNA virus, are highly polymorphic in patient samples, which may allow for rapid evolution within human hosts. To understand HCMV evolution, longitudinally sampled genomic populations from the urine and p ...

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Evolutionary algorithms were proposed to automatically find solutions to computational problems, much like evolution discovers new adaptive traits. Lately, they have been used to address challenging questions about the evolution of modularity, the genetic ...

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A quantitative algorithm was developed and applied to predict target genes of microRNAs encoded by herpesviruses. Although there is almost no conservation among microRNAs of different herpesvirus subfamilies, a common pattern of regulation emerged. The alg ...

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Intrahost and interhost assessments of viral diversity are often treated as measures of separate and distinct evolutionary processes, with numerous investigations reporting seemingly incompatible results between the two. For example, in human cytomegalovir ...

HIV-1 set-point viral load-the approximately stable value of viraemia in the first years of chronic infection-is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and the evol ...

The joint and accurate inference of selection and demography from genetic data is considered a particularly challenging question in population genetics, since both process may lead to very similar patterns of genetic diversity. However, additional informat ...

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but can be fat ...

Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections

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Variational quantum time evolution without the quantum geometric tensor

Snow-Atmosphere Humidity Exchange at the Ice Sheet Surface Alters Annual Mean Climate Signals in Ice Core Records

Generation of chiral asymmetry via helical magnetic fields

Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency

Evolution and selection of river networks: Statics, dynamics, and complexity

Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection

Linking a mutation to survival in wild mice

Entropy and order in urban street networks

Differences in the Concept of Fitness Between Artificial Evolution and Natural Selection

Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency

Direct Observation of Microscopic Solvation at the Surface of Clusters by Ultrafast Photoelectron Imaging

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe

Hox Genes Regulation During Vertebrate Development and Evolution

An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data

Limits and patterns of cytomegalovirus genomic diversity in humans

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch