Publication

Total Synthesis and Preliminary Biological Evaluation of the Natural Glycolipids Cupacinoside and Dalberoside

2026

Abstract

We report the total synthesis of the glycolipid natural products cupacinoside (1) and dalberoside (2), together with an alkynemodified analogue (3). The synthesis features two α-selective rhamnosylations and a β-selective glucosidation as key steps. Analague 3 was further derivatized to afford a BODIPY-labeled fluorescent glycolipid probe for functional and mechanistic studies. Prelinimary antimicrobial assays are reproted. We anticipate this work will facilitate synthesis and biological investigation of other glycolipid natural products and related chemical probes.

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2026

Abstract

Official source

Related concepts (6)

Biological warfare

Biological warfare, also known as germ warfare, is the use of biological toxins or infectious agents such as bacteria, viruses, insects, and fungi with the intent to kill, harm or incapacitate humans, animals or plants as an act of war. Biological weapons (often termed "bio-weapons", "biological threat agents", or "bio-agents") are living organisms or replicating entities (i.e. viruses, which are not universally considered "alive"). Entomological (insect) warfare is a subtype of biological warfare.

Biological hazard

A biological hazard, or biohazard, is a biological substance that poses a threat to the health of living organisms, primarily humans. This could include a sample of a microorganism, virus or toxin that can adversely affect human health. A biohazard could also be a substance harmful to other living beings. The term and its associated symbol are generally used as a warning, so that those potentially exposed to the substances will know to take precautions.

Chemical Weapons Convention

The Chemical Weapons Convention (CWC), officially the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction, is an arms control treaty administered by the Organisation for the Prohibition of Chemical Weapons (OPCW), an intergovernmental organization based in The Hague, The Netherlands. The treaty entered into force on 29 April 1997.