Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

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It is well-established that symptomatic cancers evade immune destruction by coalescing tumor microenvironments to suppress adaptive immunity. Additionally, mouse models of cervical and other cancers have revealed a capability of tumors to systemically indu ...

Foundation models have become a powerful tool in single-cell transcriptomics, enabling broad generalization across tasks such as cell type annotation, data integration, and drug response prediction. Yet, most current models are trained predominantly on hea ...

In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(epsilon-caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution ele ...

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Melanomas are among the deadliest cancers, with a high predisposition to metastasis and a bad prognosis in their late stages. The effectiveness of current therapeutic regimens remains suboptimal, and despite initial successes, treatment resistance emerges ...

Vimentin is a main type 3 intermediate filament protein. It seems that abnormal expression of vimentin is contributed to the appearance of the aggressive feature of cancer cells. So that it has been reported that malignancy and epithelial-mesenchymal trans ...

Colorectal cancer is the second-leading cause of cancer death worldwide. Early-stage disease can be detected with preventative medical screening and is treatable with surgical resection. Sixty-percent of patients, however, are diagnosed with advanced-stage ...

Tissues are organized in cellular niches, the composition and interactions of which can be investigated using spatial omics technologies. However, systematic analyses of tissue composition are challenged by the scale and diversity of the data. Here we pres ...

In this thesis, I present a self-organizing neural tube organoid that is strikingly similar in morphology, cell-type composition, and patterning to the mouse embryonic neural tube. When exposed to a sequence of epiblast culture conditions and neural differ ...

The human skin is a unique organ that embeds multiple functions that no artificial systems can currently replicate. Advances in materials science and engineering are driving the design of electronic skins-large-area sensor arrays that mimic some sensory mo ...

Colorectal cancer (CRC) is one of the most common cancer worldwide. Chronic inflammation contributes to CRC development and progression. Emodin, is a natural anthraquinone derivative with anti-oxidant, anti-inflammatory, and anti-tumor activities. We used ...

The body axis of vertebrate embryos is periodically subdivided into 3D multicellular units called somites. While genetic oscillations and molecular prepatterns determine the initial length-scale of somites, mechanical processes have been implicated in sett ...

Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...

Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment in ...

Understanding the external environment depends heavily on vision, audition, and touch. Like vision and audition, the human sense of touch is complex. Tactile perception is composed of multiple fundamental and physical experiences felt as changes in stiffne ...

Non-invasive and semi-invasive bioimaging is of great interest for the rapid diagnosis and efficient as well as specific treatments of biological systems affecting human health, such as cancer tissue and biofilms. Electrochemical bioimaging is one of the d ...

This paper presents the experimental results from nine full-scale concrete-filled double-skin tubular (CFDST) beam-columns. The test specimens exploited two fabrication strategies, featuring either hollow steel inner skins with corrugated geometry or ultra ...

Implantable neural interfaces are an emerging concept which is revolutionizing various domains of medicine and rehabilitation. However, the long-term efficiency and reliability of these devices is often limited, mainly attributed to the fundamental differe ...

Cylindrical light diffusers (CLDs) are often employed for the treatment of large tumors by interstitial photodynamic therapy (iPDT) and photoimmunotherapy (PIT), which involves careful treatment planning to maximize therapeutic dose coverage while minimizi ...

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

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HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine

Abstract IA02: Cancer-specific foundation models: Friend or foe in healthcare AI?

First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

Discovery and Development of Hyperthermia-Enhanced Treatments for Malignant Skin and Uveal Melanomas

Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity

Towards engineering an artificial neural tube

Electronic Skins for Healthcare Monitoring and Smart Prostheses

Emodin Inhibits Inflammation, Carcinogenesis, and Cancer Progression in the AOM/DSS Model of Colitis-Associated Intestinal Tumorigenesis

Preparation of Single-Somite Explants from Zebrafish Embryos

A new paradigm for leprosy diagnosis based on host gene expression

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Soft Touch using Soft Pneumatic Actuator-Skin as a Wearable Haptic Feedback Device

Electrochemical imaging of metabolic activity in tissue and biofilms

Experimental Investigation of the Inelastic Cyclic Behavior of Concrete-Filled Double-Skin Tubular Beam-Columns with Corrugated Inner Skins and Ultrahigh-Strength Corner Tubes

Soft materials and technologies for neural interfaces

Optimization of the Distance between Cylindrical Light Distributors Used for Interstitial Light Delivery in Biological Tissues