Publication

Gel form of ECM-scaffold prepared from bovine Nucleus Pulposus.

2011
Student Projects

Abstract

Decellularized tissues composed of extracellular matrix (ECM) and used as biologic scaffolds, have been shown to be useful for the repair of a variety of tissues. The clinical utility of such scaffolds for the tissue engineering of Nucleus Pulposus (NP) might be large but limited by the surgical procedure necessary to implant the engineered tissue. An injectable gel form of the ECM could potentially conform the required three-dimensional shape and could be delivered to site of interest by minimally invasive techniques. The goal of this project is to design a gel form of ECM scaffold, prepared from decellularized bovine NP that has been powdered. The work will include the evaluation of the gel to support in vitro growth of bovine NP-cells and the rheological characterization of its properties.

Official source

https://infoscience.epfl.ch/entities/publication/4e57f0c6-6f41-4aa8-a642-5912c60f6cc2

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2011
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/4e57f0c6-6f41-4aa8-a642-5912c60f6cc2

About this result

Related concepts (32)

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

Gel

A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state, although the liquid phase may still diffuse through this system. A gel has been defined phenomenologically as a soft, solid or solid-like material consisting of two or more components, one of which is a liquid, present in substantial quantity.

Gel electrophoresis

Gel electrophoresis is a method for separation and analysis of biomacromolecules (DNA, RNA, proteins, etc.) and their fragments, based on their size and charge. It is used in clinical chemistry to separate proteins by charge or size (IEF agarose, essentially size independent) and in biochemistry and molecular biology to separate a mixed population of DNA and RNA fragments by length, to estimate the size of DNA and RNA fragments or to separate proteins by charge.

Related publications (4)

Gel form of ECM-scaffold prepared from bovine Nucleus Pulposus.

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