Publication

In-Vivo Measurements of Atrial Repolarization Alternans Based on Standard Pacemaker Technology

Jean-Marc Vesin
2009
Conference Papers

Abstract

Introduction: It has been shown that repolarization alternans (Re-ALT), a beat-to-beat alternation in action potential duration, enhances dispersion of repolarization DOR above a critical heart rate and promotes susceptibility to ventricular arrhythmias. It is unknown whether Re-ALT is measurable in the atria using standard pacemakers and whether Re-ALT plays a role in promoting AF. Methods: two DDD pacemakers (PM) with two right atrial (RA) leads were implanted in 3 male sheep (>60kg) after ablation of the AV junction. The 1st PM was used to deliver rapid pacing (400 beats) for measurements of RA Re-ALT, the 2nd one to record a broadband unipolar RA electrogram (EGM). Re-ALT was considered present when the 2 following conditions were fulfilled: 1) beat-to-beat alternation in T-wave apex amplitude (Ta) for >4 consecutive beats, and 2) statistically different distributions of odd and even Ta (p

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https://infoscience.epfl.ch/entities/publication/4c71e23a-3869-4a4a-9882-af341530ad22

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Jean-Marc Vesin
2009
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/4c71e23a-3869-4a4a-9882-af341530ad22

About this result

Related concepts (32)

Artificial cardiac pacemaker

An artificial cardiac pacemaker (artificial pacemaker, and sometimes just pacemaker, although the term is also used to refer to the body's natural cardiac pacemaker) is a medical device, nowadays always implanted, that generates electrical pulses delivered by electrodes to one or more of the chambers of the heart, the upper atria or lower ventricles. Each pulse causes the targeted chamber(s) to contract and pump blood, thus regulating the function of the electrical conduction system of the heart.

Electrocardiography

Electrocardiography is the process of producing an electrocardiogram (ECG or EKG ), a recording of the heart's electrical activity through repeated cardiac cycles. It is an electrogram of the heart which is a graph of voltage versus time of the electrical activity of the heart using electrodes placed on the skin. These electrodes detect the small electrical changes that are a consequence of cardiac muscle depolarization followed by repolarization during each cardiac cycle (heartbeat).

Atrial fibrillation

Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) characterized by rapid and irregular beating of the atrial chambers of the heart. It often begins as short periods of abnormal beating, which become longer or continuous over time. It may also start as other forms of arrhythmia such as atrial flutter that then transform into AF. Episodes can be asymptomatic. Symptomatic episodes may involve heart palpitations, fainting, lightheadedness, shortness of breath, or chest pain.

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In-Vivo Measurements of Atrial Repolarization Alternans Based on Standard Pacemaker Technology

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