No DDRama at chromosome ends: TRF2 takes centre stage

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First developments towards producing inductive magnetic sensors using state-of-the-art photolithography techniques

Duccio Testa, Ambrine Douhane, Marcus Cemes

Inductive magnetic sensors are needed for tokamak operation to provide the low-frequency (LF) measurements leading to the equilibrium reconstruction and to monitor the higher frequency (HF) instabilities; the HF magnetic sensors are often also used as a ba ...

2023

Preomic profile of BxPC-3 cells after treatment with BRC4

Andrea Cavalli

BRCA2 and RAD51 are two proteins that play a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. BRCA2 assists RAD51 fibrillation and defibrillation through binding with its eight BRC repeats, with BRC4 being one of the ...

ELSEVIER2023

Impact of the turbulence wavenumber spectrum and probing beam geometry on Doppler reflectometry perpendicular velocity measurements

Frank Nüesch, Anita Frank

The perpendicular propagation velocity of turbulent density fluctuations is an important parameter in fusion plasmas, since sheared plasma flows are crucial for reducing turbulence, and thus an essential input parameter for turbulent transport simulations. ...

IOP Publishing Ltd2023

An experimental and computational study of tokamak plasma turbulence

Aylwin Iantchenko

Turbulence driven by small-scale instabilities results in strong heat and particle transport, which significantly shortens the confinement time and prevents the formation of a self-sustained plasma reaction in magnetic confinement devices. Control and poss ...

EPFL2023

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

Béatrice Kunz, Didier Trono, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Audrey Geneviève Chuat, Francisco De Magalhães Sarmento R De Mesquita, Lucie Josepha Marie Bracq, Joana Carlevaro Fita, Nattawadee Panyain

SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Previous observati ...

Nature Research2023

Investigation of the interplay between Electron-Cyclotron waves, suprathermal electrons and turbulence in tokamak plasmas

Jean Arthur Cazabonne

Electron-Cyclotron waves are routinely used in tokamaks to heat the plasma and to drive current through the electron channel. Their unique ability to drive very localized current renders them the main foreseen tool for neoclassical tearing mode mitigation ...

EPFL2023

Validation of 2D T e and n e measurements made with Helium imaging spectroscopy in the volume of the TCV divertor

Patrick Blanchard, Basil Duval, Holger Reimerdes, Christian Gabriel Theiler, Hugo De Oliveira, Cedric Kar-Wai Tsui, Nicola Offeddu, Filippo Bagnato, Lorenzo Martinelli, Sophie Danielle Angelica Gorno, Claudia Colandrea, Dmytry Mykytchuk, Artur Perek

Multi-spectral imaging of helium atomic emission (HeMSI) has been used to create 2D poloidal maps of T-e and ne in TCV's divertor. To achieve these measurements, TCV's MANTIS multispectral cameras (Perek et al 2019 Rev. Sci. Instrum. 90 123514) simultaneou ...

IOP Publishing Ltd2023

Identification and characterization of proteins that protect human telomeres from fragility

Anna Christina Näger

Difficulties to replicate telomeres - the ends of our chromosomes - can cause telomere shortening and genome instability. These difficulties are due to the repetitive DNA sequence and distinct structures at telomeres that challenge the semi-conservative DN ...

EPFL2022

TFIIH moonlighting at telomeres

Joachim Lingner, Galina Glousker

Although telomeres are essential for chromosome stability, they represent fragile structures in our genome. Telomere shortening occurs during aging in cells lacking telomerase due to the end replication problem. In addition, recent work uncovered that the ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2022

Excitation of Alfven eigenmodes by fusion-born alpha-particles in D-He-3 plasmas on JET

Henri Weisen, Javier García Hernández

Alfven eigenmode (AE) instabilities driven by alpha-particles have been observed in D-He-3 fusion experiments on the Joint European Torus (JET) with the ITER-like wall. For the efficient generation of fusion alpha-particles from D-He-3 fusion reaction, the ...

2022

Magnetic control of tokamak plasmas through deep reinforcement learning

Basil Duval, Ambrogio Fasoli, Jean-Marc Moret, Olivier Sauter, Stefano Coda, Jonas Buchli, Federico Alberto Alfredo Felici, Antoine Pierre Emmanuel Alexis Merle, Cristian Galperti, Francesco Carpanese, Federico Pesamosca, Cristian Sommariva, Jonas Degrave, Brendan Tracey

Nuclear fusion using magnetic confinement, in particular in the tokamak configuration, is a promising path towards sustainable energy. A core challenge is to shape and maintain a high-temperature plasma within the tokamak vessel. This requires high-dimensi ...

2022

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutS gamma complex

Alexander Woglar

Crossover formation is essential for proper segregation of homologous chromosomes during meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with cyclin-like protein COSA-1 to promote crossover formation by promoti ...

National Academy of Sciences2022

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