Template-assisted protein design: Chimeric TASP by chemoselective ligation

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The near arrival of electric vehicles on the car market generates a need for new models in order to understand and predict the impact it has on the current market shares. This research aims at providing contributions regarding several issues related to the evaluation of the demand for electric vehicles, i.e. related to the survey design, demand models and forecasting. In this paper we focus on the first of these three methodological issues. We present the design of a stated preference survey which will enab

Building acoustic beamformers is a problem whose solution is hindered by the wide-band nature of audible sound. In order to achieve a consistent directional response over a wide range of frequencies, a conventional acoustic beamformer needs a high number of discrete loudspeakers and be large enough to achieve a desired low-frequency performance. The acoustic beamformer design described in this paper uses measurement-based optimized beamforming for loudspeakers mounted on a rigid cylindrical baffle. Super-di

This research project presents a corporation of architects, mathematicians and computer scientists. The team researches new methods for the efficient realization of complex architectural shapes. The aim is to develop computer-aided solutions which optimize the design and production of free-form surfaces. Therefore, the team worked out a new geometric design method. The method studied provides new form-finding possibilities while satisfying a certain number of material and construction constraints.

The objective of the present work is that of making a contribution to the performance-based seismic design of RC buildings with U-shaped walls. Since U-shaped walls are often placed at the perimeter of a building and are typically stiffer and stronger than other lateral strength providing structural elements, many of these buildings possess in-plan strength and stiffness eccentricities and are therefore prone to damage due to twist-induced displacements. The work focuses therefore on two aspects of the desi

This chapter describes ModelLib, a web-based platform for collecting models from different domains (e.g., electrical, mechanical, or electromechanical) and levels of abstractions (e.g., system, circuit, or device level). Use cases for this tool are presented, which show how it can support the design process of complex heterogeneous AMS systems through better reuse of existing models for tasks like architecture exploration, system validation, and creation of more and more elaborated models of the system. The

Hybrid Car-Parrinello QM/MM calcns. are used to investigate the reaction mechanism of hydrolysis of a common b-lactam substrate (cefotaxime) by the monozinc b-lactamase from Bacillus cereus (BcII). The calcns. suggest a fundamental role for an active site water in the catalytic mechanism. This water mol. binds the zinc ion in the first step of the reaction, expanding the zinc coordination no. and providing a proton donor adequately oriented for the second step. The free energy barriers of the two reaction s

We address the design of complex monolithic systems, where processing cores generate and consume a varying and large amount of data, thus bringing the communication links to the edge of congestion. Typical applications are in the area of multi-media processing. We consider a mesh-based Networks on Chip (NoC) architecture, and we explore the assignment of cores to mesh cross-points so that the traffic on links satisfies bandwidth constraints. A single-path deterministic routing between the cores places high

Component composition and Web-service composition have in common that the usage pattern of a certain black-box component or Web-service needs to be described precisely. Because usually many interactions between the client and the service provider are required to obtain a certain desired functionality, one would hope to find the specification of permissible interaction sequences with the service provider in service description formalisms, such as the WSDL. This paper shows an approach to automatically genera

The experiments of Cable-in conduit conductor (CICC) short samples with high proportion of segregated copper strands have been carried out in SULTAN facility last September. These experiments aimed to investigate transient stability and AC losses of CICC conductor coated with different resistive barriers (Pb-30Sn-2Sb or Ni plating on strands) and to check the design of PF and TF CICC for HT-7U magnets. The resistive barriers' influences on the stability and AC losses of CICC are evaluated. These experimenta

This paper presents the mechanical slit mask designed for the Near Infrared Spectrograph of the James Webb Space Telescope. This mechanism is designed to function at a cryogenic temperature of 30K, in vacuum. The reconfigurable mask allows to form 24 optical slits in a 137 x 137 mm2 field of view. The slit length is fixed (4.8 mm) and their width can range from 50 μm to 137 mm. The slit positioning accuracy is ± 5 μm and the slit width accuracy is ± 8 μm. The paper concentrates on the working principle of t

A novel MEMS device architecture: the SOI SG-MOSFET, which combines a solid- state MOS transistor and a suspended metal membrane in a unique metal-over- gate architecture, is proposed. A unified physical analytical model (weak, moderate and strong inversions) is developed and used to investigate main electrostatic characteristics in order to provide first-order design criteria for low-voltage operation and high-performance. It is demonstrated that the use of a thin gate oxide (

The reliable evaluation of the performance of watermarking algorithms is difficult. An important aspect in this process is the assessment of the visibility of the watermark. In this paper, we address this issue and propose a methodology for evaluating the visual quality of watermarked video. Using a software tool that measures different types of perceptual video artifacts, we determine the most relevant impairments and design the corresponding objective metrics. We demonstrate their performance through subj

Template-assisted protein design: Chimeric TASP by chemoselective ligation

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Modeling demand for electric vehicles: the effect of car users' attitudes and perceptions

Design of a Compact Cylindrical Loudspeaker Array for Spatial Sound Reproduction

Iterative Geometric Design for Architecture

Seismic design of torsionally eccentric buildings with U-shaped RC walls

ModelLib: A Web-Based Platform for Collecting Behavioural Models and Supporting the Design of AMS Systems

Water-Assisted Reaction Mechanism of Monozinc b-Lactamases

Bandwidth-Constrained Mapping of Cores onto NoC Architectures

Generating Synchronization Contracts for Web Services

Test results and analyses of conductor short samples for HT-7U

Mechanical Slit Mask Mechanism for the James Webb Space Telescope Spectrometer

Modeling and design of a low-voltage SOI suspended-gate MOSFET (SG- MOSFET) with a metal-over-gate architecture

Perceptual Quality Assessment for Video Watermarking