Publications related to Rational strain design with minimal phenotype perturbation

Related publications (16)

CORTEX experiments, Part III: Experimental determination of the zero power transfer function of AKR-2 with reliable uncertainties

The transfer function is an important characteristic quantity of a nuclear reactor, since it contains the kinetic parameters. It expresses the response of a nuclear reactor to a disturbance of a certain frequency. If it is determined experimentally, it can ...

2024

Multi-Annual Year-on-Year: Minimising the Uncertainty in Photovoltaic System Performance Loss Rates

Christophe Ballif, Hugo James André Quest

The performance loss rate (PLR) is a key parameter in the assessment of photovoltaic (PV) systems' long-term performance and reliability. Despite the lack of industry-wide consensus and standardised methods for extracting PLR values from field data, the ye ...

2024

Reducing Aerosol Forcing Uncertainty by Combining Models With Satellite and Within-The-Atmosphere Observations: A Three-Way Street

Athanasios Nenes

Aerosol forcing uncertainty represents the largest climate forcing uncertainty overall. Its magnitude has remained virtually undiminished over the past 20 years despite considerable advances in understanding most of the key contributing elements. Recent wo ...

AMER GEOPHYSICAL UNION2023

Influence of Uncertainty of Body Permittivity on Achievable Radiation Efficiency of Implantable Antennas-Stochastic Analysis

Anja Skrivervik

Design of medical sensor implants is very challenging due to numerous restrictions in terms of size and biological acceptability. In addition, large absorption and reflection of electromagnetic waves in body tissues significantly degrades the communication ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Mapping and Analysis of the Complexity of Lipid Metabolism for Applications in Health and Sustainability

Vassily Hatzimanikatis, Sofia Tsouka

Metabolism is a network of biotransformations that sustain life in cells. Over the past decades, metabolism has been studied in multiple contexts, ranging from medicine to industrial manufacturing. In particular, lipid metabolism has been linked to various ...

EPFL2020

TDCOSMO: I. An exploration of systematic uncertainties in the inference of H-0 from time-delay cosmography

Frédéric Courbin, Hung-Hsu Chan, Martin Raoul Robert Millon, Aymeric Alexandre Galan

Time-delay cosmography of lensed quasars has achieved 2.4% precision on the measurement of the Hubble constant, H0. As part of an ongoing effort to uncover and control systematic uncertainties, we investigate three potential sources: 1- stellar kinematics, ...

EDP SCIENCES S A2020

Quantifying uncertainties in contact mechanics of rough surfaces using the multilevel Monte Carlo method

Fabio Nobile, Sebastian Krumscheid, Valentine Ginette Madeleine Rey

We quantify the effect of uncertainties on quantities of interest related to contact mechanics of rough surfaces. Specifically, we consider the problem of frictionless non adhesive normal contact between two semi infinite linear elastic solids subject to u ...

2019

Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks

Dimitrios Alexandros Kyparissidis, Vassily Hatzimanikatis

The increasing availability of large metabolomics datasets enhances the need for computational methodologies that can organize the data in a way that can lead to the inference of meaningful relationships. Knowledge of the metabolic state of a cell and how ...

Elsevier2017

Temperature-strain discrimination in distributed optical fiber sensing using phase-sensitive optical time-domain reflectometry

Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Xin Lu

A method based on coherent Rayleigh scattering distinctly evaluating temperature and strain is proposed and experimentally demonstrated for distributed optical fiber sensing. Combining conventional phase-sensitive optical time-domain domain reflectometry ( ...

Optical Society of America2017

Metabolic control of muscle and muscle stem cell function

Hongbo Zhang

Skeletal muscle composed of myofibers and a small amount of muscle stem cells (MuSCs). It plays important roles in energy metabolism. Some of the key metabolites, such as NAD+ and acetyl-CoA were recently found to regulate muscle and MuSCs function. Most o ...

EPFL2016

A balancing market under uncertainty with a rolling horizon for European Market Structure

Sidi-Rachid Cherkaoui, Farzaneh Abbaspourtorbati

IEEE2015

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Rolf Gruetter, Arnaud Comment, Hongxia Lei, Josefina Adriana Maria Bastiaansen, Tian Cheng

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Elsevier2015

Performance-Driven Measurement System Design for Structural Identification

Ian Smith, James-Alexandre Goulet

Much progress has been achieved in the research field of structural identification, which is attributable to a better understanding of uncertainties, improvement in sensor technologies, and cost reductions. However, data interpretation remains a bottleneck ...

American Society of Civil Engineers2013

Proposition of methodology for optimization of energy system design under uncertainty

François Maréchal, Matthias Dubuis

Current superstructure size for energy system design is increasing with computing facility improvement. Despite such approach allows to link and to analyse a lot of elements, demonstrating the advantage of a global optimization, non-negligible uncertaintie ...

Elsevier Science Bv2012

Production of biofuels and biochemicals: in need of an ORACLE

Vassily Hatzimanikatis, Ljubisa Miskovic

The engineering of cells for the production of fuels and chemicals involves simultaneous optimization of multiple objectives, such as specific productivity, extended substrate range and improved tolerance – all under a great degree of uncertainty. The achi ...

Elsevier2010

Development and application of objective uncertainty measures for nuclear power plant transient analysis

Paolo Vinai

For the development, design and licensing of a nuclear power plant (NPP), a sound safety analysis is necessary to study the diverse physical phenomena involved in the system behaviour under a wide range of operational and transient conditions. Such studies ...

EPFL2007