Publication

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Paul Joseph Dyson, Olivier Pierre Zava
2012
Journal Articles

Abstract

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metallacages, Ru-6(p-cymene)(6)(OO boolean AND OO)(3)(tpt)(2) (OO boolean AND OO = 5,8-dioxydo-1,4-naphtaquinonato (donq) 1 and 6,11-dioxydo-5,12-naphtacenedionato (dotq) 2; tpt = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine). The host guest properties of guest subset of 1 and guest subset of 2 were studied in solution by NMR and UV-vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water-soluble host guest systems and the pyrenyl-dendrimers was evaluated on human ovarian cancer cells.

Official source

https://infoscience.epfl.ch/entities/publication/48753f6d-b1c5-419e-b732-1e7803d12584

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Paul Joseph Dyson, Olivier Pierre Zava
2012
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/48753f6d-b1c5-419e-b732-1e7803d12584

About this result

Related concepts (11)

Ovarian cancer

Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different cell types including epithelial cells, germ cells, and stromal cells. When these cells become abnormal, they have the ability to divide and form tumors. These cells can also invade or spread to other parts of the body. When this process begins, there may be no or only vague symptoms.

Ovarian follicle

An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle. At the time of puberty, women have approximately 200,000 to 300,000 follicles, each with the potential to release an egg cell (ovum) at ovulation for fertilization. These eggs are developed once every menstrual cycle with around 450–500 being ovulated during a woman's reproductive lifetime. Ovarian follicles are the basic units of female reproductive biology.

BRCA1

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 (ˌbrækəˈwʌn) gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. BRCA1 is a human tumor suppressor gene (also known as a caretaker gene) and is responsible for repairing DNA. BRCA1 and BRCA2 are unrelated proteins, but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired.

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