Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

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In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...

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Author summary During development, enhancer sequences tightly regulate the spatio-temporal expression of target genes often located hundreds of kilobases away. This complex process is made possible by the folding of chromatin into domains, which are separa ...

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Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanist ...

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Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

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Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

Induction of a chromatin boundary in vivo upon insertion of a tad border

Ultraflexible flow directed device and system

GCN2 adapts protein synthesis to scavenging-dependent growth

Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos

Toward a mechanistic understanding of variable chromatin modules

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos