Publication

A new flexible microfabricated polyimide-based platinum electrodes for stimulation of rat retinal tissue in vitro and recording using a multi-electrode array

Philippe Renaud
2008
Conference Papers

Abstract

We present a new flexible micro-fabricated polyimide-based platinum (Pt) array of four planar electrodes system for local stimulation of the rat retinal photoreceptor layer and simultaneous extracellular recording (ECR) from large population of retinal ganglion cells (RGCs) using the MEA60 setup (Multi Channel Systems) in vitro conditions. Our results revealed that RGCs present On or/and Off light-driven responses on a majority of recorded sites. Local electrical stimulation induced excitatory responses in a small number of RGCs hypothesised to the poor electrode- tissue interfacial contact. Two approaches are proposed to enhance the electrode- tissue interfacial contact to improve the efficiency of stimulation.

Official source

https://infoscience.epfl.ch/entities/publication/47ccaafb-6e15-43b2-a068-931e0650ffeb

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Philippe Renaud
2008
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/47ccaafb-6e15-43b2-a068-931e0650ffeb

About this result

Related concepts (18)

Retinal ganglion cell

A retinal ganglion cell (RGC) is a type of neuron located near the inner surface (the ganglion cell layer) of the retina of the eye. It receives visual information from photoreceptors via two intermediate neuron types: bipolar cells and retina amacrine cells. Retina amacrine cells, particularly narrow field cells, are important for creating functional subunits within the ganglion cell layer and making it so that ganglion cells can observe a small dot moving a small distance.

Microelectrode array

Microelectrode arrays (MEAs) (also referred to as multielectrode arrays) are devices that contain multiple (tens to thousands) microelectrodes through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry. There are two general classes of MEAs: implantable MEAs, used in vivo, and non-implantable MEAs, used in vitro. Neurons and muscle cells create ion currents through their membranes when excited, causing a change in voltage between the inside and the outside of the cell.

Single-unit recording

In neuroscience, single-unit recordings (also, single-neuron recordings) provide a method of measuring the electro-physiological responses of a single neuron using a microelectrode system. When a neuron generates an action potential, the signal propagates down the neuron as a current which flows in and out of the cell through excitable membrane regions in the soma and axon. A microelectrode is inserted into the brain, where it can record the rate of change in voltage with respect to time.

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A new flexible microfabricated polyimide-based platinum electrodes for stimulation of rat retinal tissue in vitro and recording using a multi-electrode array

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