Host genomics of SARS-CoV-2 infection

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The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses. ...

Digital contact tracing substantially improves the identification of high-risk contacts during pandemics. Despite several attempts to encourage people to use digital contact-tracing applications by developing and rolling out decentralized privacy-preservin ...

Two anaerobic, tetrachloroethene- (PCE-) respiring bacterial isolates, designated strain ACSDCE T and strain ACSTCE, were characterized using a polyphasic approach. Cells were Gram-stain-negative, motile, non-spore-forming and shared a vibrioid- to spirill ...

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

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5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite control, yet 5mC has also been lost in many lineages. The causes for 5mC retention an ...

Background Immersive virtual reality (iVR)-based digital therapeutics are gaining clinical attention in the field of pain management. Based on known analogies between pain and dyspnoea, we investigated the effects of visual respiratory feedback on persiste ...

DNA-binding proteins physically interact with the DNA and directly affect genomic functions. The eukaryotic genome is compacted into chromatin, limiting the DNA access to nuclear factors. In this Ph.D. thesis, I explored the dynamic mechanisms, that allow ...

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Regulation of gene expression is a complex but highly guided process. While genomic technologies and computational approaches have allowed high-throughput mapping of cis-regulatory elements (CREs) and their interactions in 3D, their precise role in regulat ...

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Background: Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryo- genesis to innate ...

Aerobic granular sludge (AGS) consists of a microbial consortium that has an important role in wastewater treatment. This study investigates AGS microorganisms cultivated in a laboratory-scale sequencing batch reactor. Metagenomic sequencing was conducted ...

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Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus's spike protein and ce ...

Host genomics of SARS-CoV-2 infection

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Modeling, analysis, and design of complex biological networks

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

Systematic benchmarking of single-cell ATAC-sequencing protocols

DP-ACT: Decentralized Privacy-Preserving Asymmetric Digital Contact Tracing

Sulfurospirillum diekertiae sp. nov., a tetrachloroethene-respiring bacterium isolated from contaminated soil

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out: An application to the Italian scenario

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

Virtual reality intervention alleviates dyspnoea in patients recovering from COVID-19 pneumonia

Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins

Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

Chromatin modules and their implication in genomic organization and gene regulation

Challenges of COVID-19 Case Forecasting in the US, 2020-2021

Associations of genetic and infectious risk factors with coronary heart disease

The cost of adaptability: resource availability constrains functional stability under pulsed disturbances

Statistical learning quantifies transposable element-mediated cis-regulation

Microbial genome collection of aerobic granular sludge cultivated in sequencing batch reactors using different carbon source mixtures

Benchmarking informatics approaches for virus discovery: caution is needed when combining in silico identification methods

Screening for drivers of SARS-CoV-2 uptake