Publication

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

Patrick Aebischer, Didier Trono, Isabelle Barde, Christopher Towne, Anna Claire Groner
2009
Journal Articles

Abstract

KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.

Official source

https://infoscience.epfl.ch/entities/publication/47404625-bb22-44b2-b8e6-1a468efeb39c

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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

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