Publication

Convenient method for the synthesis of N-alkyl-substituted 4-hydroxy-1,2,3,4-tetrahydroisoquinolines

Manfred Schlosser
1990
Journal Articles

Abstract

Title compds. I [R = alkyl, propargyl, (un)substituted benzyl] and II (R = Me, CH2Ph, CH2C6H4Cl-2) were prepd., usually in >=50% yield, by successive treatment of alkoxy-substituted N-alkylbenzylamines with BrCH2CH(OEt)2 and HCl. [on SciFinder (R)]

Official source

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