Human Genome ProjectThe Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning for the project started after it was adopted in 1984 by the US government, and it officially launched in 1990.
Large language modelA large language model (LLM) is a language model characterized by its large size. Their size is enabled by AI accelerators, which are able to process vast amounts of text data, mostly scraped from the Internet. The artificial neural networks which are built can contain from tens of millions and up to billions of weights and are (pre-)trained using self-supervised learning and semi-supervised learning. Transformer architecture contributed to faster training.
Human genomeThe human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs.
Ensembl genome database projectEnsembl genome database project is a scientific project at the European Bioinformatics Institute, which provides a centralized resource for geneticists, molecular biologists and other researchers studying the genomes of our own species and other vertebrates and model organisms. Ensembl is one of several well known genome browsers for the retrieval of genomic information. Similar databases and browsers are found at NCBI and the University of California, Santa Cruz (UCSC).
Google DeepMindDeepMind Technologies Limited, doing business as Google DeepMind, is a British-American artificial intelligence research laboratory which serves as a subsidiary of Google. Founded in the UK in 2010, it was acquired by Google in 2014, becoming a wholly owned subsidiary of Google parent company Alphabet Inc. after Google's corporate restructuring in 2015. The company is based in London, with research centres in Canada, France, and the United States.
Visual programming languageIn computing, a visual programming language (visual programming system, VPL, or, VPS) or block coding is a programming language that lets users create programs by manipulating program elements graphically rather than by specifying them textually. A VPL allows programming with visual expressions, spatial arrangements of text and graphic symbols, used either as elements of syntax or secondary notation.
GenomicsGenomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism.
Inter-rater reliabilityIn statistics, inter-rater reliability (also called by various similar names, such as inter-rater agreement, inter-rater concordance, inter-observer reliability, inter-coder reliability, and so on) is the degree of agreement among independent observers who rate, code, or assess the same phenomenon. Assessment tools that rely on ratings must exhibit good inter-rater reliability, otherwise they are not valid tests. There are a number of statistics that can be used to determine inter-rater reliability.
Visual StudioVisual Studio is an integrated development environment (IDE) from Microsoft. It is used to develop computer programs including websites, web apps, web services and mobile apps. Visual Studio uses Microsoft software development platforms such as Windows API, Windows Forms, Windows Presentation Foundation, Windows Store and Microsoft Silverlight. It can produce both native code and managed code. Visual Studio includes a code editor supporting IntelliSense (the code completion component) as well as code refactoring.
Reinforcement learning from human feedbackIn machine learning, reinforcement learning from human feedback (RLHF) or reinforcement learning from human preferences is a technique that trains a "reward model" directly from human feedback and uses the model as a reward function to optimize an agent's policy using reinforcement learning (RL) through an optimization algorithm like Proximal Policy Optimization. The reward model is trained in advance to the policy being optimized to predict if a given output is good (high reward) or bad (low reward).
Visual Basic (.NET)Visual Basic (VB), originally called Visual Basic .NET (VB.NET), is a multi-paradigm, object-oriented programming language, implemented on .NET, Mono, and the .NET Framework. Microsoft launched VB.NET in 2002 as the successor to its original Visual Basic language, the last version of which was Visual Basic 6.0. Although the ".NET" portion of the name was dropped in 2005, this article uses "Visual Basic [.NET]" to refer to all Visual Basic languages released since 2002, in order to distinguish between them and the classic Visual Basic.
Chromosome 3Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans 201 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA in cells. The following are some of the gene count estimates of human chromosome 3. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction).
Chromosome 6Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 172 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation. The centromere of chromosome 6 illustrates an interesting example of centromere evolution.
Fleiss' kappaFleiss' kappa (named after Joseph L. Fleiss) is a statistical measure for assessing the reliability of agreement between a fixed number of raters when assigning categorical ratings to a number of items or classifying items. This contrasts with other kappas such as Cohen's kappa, which only work when assessing the agreement between not more than two raters or the intra-rater reliability (for one appraiser versus themself). The measure calculates the degree of agreement in classification over that which would be expected by chance.
Visual J SharpVisual J# (pronounced "jay-sharp") is a discontinued implementation of the J# programming language that was a transitional language for programmers of Java and Visual J++ languages, so they could use their existing knowledge and applications with the .NET Framework. It was introduced in 2002 and discontinued in 2007, with support for the final release of the product continuing until October 2017. J# worked with Java bytecode as well as source so it could be used to transition applications that used third-party libraries even if their original source code was unavailable.
Visual Studio CodeVisual Studio Code, also commonly referred to as VS Code, is a source-code editor made by Microsoft with the Electron Framework, for Windows, Linux and macOS. Features include support for debugging, syntax highlighting, intelligent code completion, snippets, code refactoring, and embedded Git. Users can change the theme, keyboard shortcuts, preferences, and install extensions that add functionality. In the Stack Overflow 2023 Developer Survey, Visual Studio Code was ranked the most popular developer environment tool among 86,544 respondents, with 73.
Public–private partnershipA public–private partnership (PPP, 3P, or P3) is a long-term arrangement between a government and private sector institutions. Typically, it involves private capital financing government projects and services up-front, and then drawing revenues from taxpayers and/or users over the course of the PPP contract. Public–private partnerships have been implemented in multiple countries and are primarily used for infrastructure projects. They have been employed for building, equipping, operating and maintaining schools, hospitals, transport systems, and water and sewerage systems.
Cohen's kappaCohen's kappa coefficient (κ, lowercase Greek kappa) is a statistic that is used to measure inter-rater reliability (and also intra-rater reliability) for qualitative (categorical) items. It is generally thought to be a more robust measure than simple percent agreement calculation, as κ takes into account the possibility of the agreement occurring by chance. There is controversy surrounding Cohen's kappa due to the difficulty in interpreting indices of agreement.
Water privatizationWater privatization is short for private sector participations in the provision of water services and sanitation. Water privatization has a variable history in which its popularity and favorability has fluctuated in the market and politics. One of the common forms of privatization is public–private partnerships (PPPs). PPPs allow for a mix between public and private ownership and/or management of water and sanitation sources and infrastructure. Privatization, as proponents argue, may not only increase efficiency and service quality but also increase fiscal benefits.
