Publication

Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

Nicolai Cramer, Tanguy Jean Daniel Saget
2013
Journal Articles

Abstract

The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.

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Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

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