Evaluating the influence of induced passive torques in the simulation of time-varying human poses

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Background: Exoskeletons for lower and upper extremities have been introduced in neurorehabilitation because they can guide the patient's limb following its anatomy, covering many degrees of freedom and most of its natural workspace, and allowing the contr ...

Solute accelerated cross-slip of pyramidal < c + a > screw dislocations has recently been recognized as a crucial mechanism in enhancing the ductility of solid-solution Mg alloys. In pure Mg, cross-slip is ineffective owing to the energy difference between ...

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to ...

Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord of 30 hpf zebrafish embryos and it ...

Hydrogen embrittlement (HE) is a ubiquitous and catastrophic mode of fracture in metals. Here, embrittlement is considered as an intrinsic ductile-brittle transition at the crack tip, where H at the crack tip can reduce the stress intensity K-Ic for cleava ...

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...

The yield strength of random metal alloys, i.e. alloys with random occupation of the crystalline lattice sites by the elemental constituent atoms all considered as solutes, is primarily understood as controlled by solute/dislocation interactions. Solute-so ...

Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials correspo ...

Despite the advances achieved in understanding the molecular biology of muscle cells in the past decades, there is still need for effective treatments of muscular degeneration caused by muscular dystrophies and for counteracting the muscle wasting caused b ...

Despite the advances in the field of brain computer interfaces (BCI), the use of the sole electroencephalography (EEG) signal to control walking rehabilitation devices is currently not viable in clinical settings, due to its unreliability. Hybrid interface ...

The skeletal fibers have different embryological origin; the extraocular and jaw-closer muscles develop from prechordal mesoderm while the limb and trunk muscles from somites. These different origins characterize also the adult muscle stem cells, known as ...

Neuromuscular diseases are degenerative and, thus far, incurable disorders that lead to large muscle wasting. They result in constant deterioration of activities of daily living and in particular of ambulation. Some common types include Duchenne muscular d ...

The integration of renewable energy in the built environment, improving the energy efficiency of buildings, and optimizing distributed energy systems are three interconnected activities that are central for the transition to sustainable cities. Here, a met ...

While intermittent hypoxic training (IHT) has been reported to evoke cellular responses via hypoxia inducible factors (HIFs) but without substantial performance benefits in endurance athletes, we hypothesized that repeated sprint training in hypoxia could ...

We consider sets L = {l(1),..., l(n)} of n labeled lines in general position in R-3, and study the order types of point sets {p(1),..., p(n)} that stem from the intersections of the lines in L with (directed) planes Pi, not parallel to any line of L, that ...

The present study essentially employs a thin-layer interface model for filled rock joints to analyze wave propagation across the jointed rock masses. The thin-layer interface model treats the rough-surfaced joint and the filling material as a continuum med ...

This paper presents design and characterization of a new type of structural joint which can vary its stiffness through actuation. Stiffness variation is employed to control the dynamic response of frame structures equipped with such joints. The joint is ma ...

Despite increasing attention for the recently found ferro- and antiferroelectric properties, the polymorphism in hafnia- and zirconia-based thin films is still not sufficiently understood. In the present work, we show that it is important to have a good qu ...

The aim of this study was to investigate the alteration of the gait pattern in 25 children with Duchenne muscular dystrophy, using body-worn inertial sensors during a long walking distance. Normalized spatiotemporal gait parameters and their variability we ...

Evaluating the influence of induced passive torques in the simulation of time-varying human poses

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Evaluation of the effects of the Arm Light Exoskeleton on movement execution and muscle activities: a pilot study on healthy subjects

Analysis of double cross-slip of pyramidal I < c plus a > screw dislocations and implications for ductility in Mg alloys

NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

A decohesion pathway for hydrogen embrittlement in nickel: Mechanism and quantitative prediction

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Metabolic rescue of muscle and muscle stem cells in muscle disease

Effect of solute-solute interactions on strengthening of random alloys from dilute to high entropy alloys

Strategies for improving the repair of focal cartilage defects

Molecular and cell-based therapies for muscle degenerations: a road under construction

Hybrid Human-Machine Interface for Gait Decoding Through Bayesian Fusion of EEG and EMG Classifiers

Myogenic potential of canine craniofacial satellite cells

Wearable exoskeletons to support ambulation in people with neuromuscular diseases, design rules and control

Integrating urban form and distributed energy systems: Assessment of sustainable development scenarios for a Swiss village to 2050

Significant Molecular and Systemic Adaptations after Repeated Sprint Training in Hypoxia

Cross-sections of line configurations in R-3 and (d-2)-flat configurations in R-d

A thin-layer interface model for wave propagation through filled rock joints

Design and characterization of variable stiffness structural joints

Local structural investigation of hafnia-zirconia polymorphs in powders and thin films by X-ray absorption spectroscopy

Gait Assessment in Duchenne Muscular Dystrophy Children during Long-Distance Walking