Publication

A novel chemical approach to biotinylated glycosulfopeptides

2001
Conference Papers

Abstract

A symposium report. A novel chem. approach for the synthesis of biotinylated glycosulfopeptides uses two different chemoselective ligation reactions in the presence of the sulfate moiety. The strategy was applied to the synthesis of a peptide sequence derived from the N-terminal region of the P-selectin glycoprotein ligand 1 (PSGL-1), a major ligand of the selectin family involved in cell-cell adhesion. [on SciFinder (R)]

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2001
Conference Papers

Abstract

Official source

Related concepts (14)

Cell adhesion molecule

Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. In essence, CAMs help cells stick to each other and to their surroundings. CAMs are crucial components in maintaining tissue structure and function. In fully developed animals, these molecules play an integral role in generating force and movement and consequently ensuring that organs are able to execute their functions normally.

Cell adhesion

Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released by cells into spaces between them. Cells adhesion occurs from the interactions between cell-adhesion molecules (CAMs), transmembrane proteins located on the cell surface.

Cell junction

Cell junctions or junctional complexes, are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. They also maintain the paracellular barrier of epithelia and control paracellular transport. Cell junctions are especially abundant in epithelial tissues. Combined with cell adhesion molecules and extracellular matrix, cell junctions help hold animal cells together.

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A novel chemical approach to biotinylated glycosulfopeptides

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