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The invention regards a method for screening for interactions between two compounds provided in libraries. The invention in particular provides a method for screening interactions, such as a binding between two molecules or macromolecules, that is not limited to a classical screening by bait and prey setup, and therefore allows for a high-complexity screening of large candidate libraries, including screening for immunological interactions such as interactions between T-cells and antigen presenting cells, or B-cells and their antigenic targets.
Douglas Hanahan, Krisztian Homicsko, Morgane Marie Lecointre, Jeremy Gilles Louis Guillot, Marjorie Gabrielle Marie Cayatte, Dilara Selin Ozdoganlar
Alexander Myasnikov, Emiko Uchikawa