Increasing Availability in Distributed Storage Systems via Clustering

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Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Sebastian Maerkl, Ivan Istomin, Evan James Olson, Shiyu Cheng, Amir Shahein, Maria Lopez Malo

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Nature Portfolio2022

Subspace clustering in high-dimensions: Phase transitions & Statistical-to-Computational gap

Florent Gérard Krzakala, Lenka Zdeborová, Bruno Loureiro, Luca Pesce, Bruno Loureiro

A simple model to study subspace clustering is the high-dimensional k -Gaussian mixture model where the cluster means are sparse vectors. Here we provide an exact asymptotic characterization of the statistically optimal reconstruction error in this model i ...

2022

Binary Perceptron: Efficient Algorithms Can Find Solutions in a RareWell-Connected Cluster

Emmanuel Abbé

It was recently shown that almost all solutions in the symmetric binary perceptron are isolated, even at low constraint densities, suggesting that finding typical solutions is hard. In contrast, some algorithms have been shown empirically to succeed in fin ...

ASSOC COMPUTING MACHINERY2022

System Support for Robust Distributed Learning

Arsany Hany Abdelmessih Guirguis

Machine learning (ML) applications are ubiquitous. They run in different environments such as datacenters, the cloud, and even on edge devices. Despite where they run, distributing ML training seems the only way to attain scalable, high-quality learning. B ...

EPFL2022

Do the majority of stars form as gravitationally unbound?

Richard Irving Anderson

Context. Some of the youngest stars (age less than or similar to 10 Myr) are clustered, while many others are observed scattered throughout star forming regions or in complete isolation. It has been intensively debated whether such scattered or isolated st ...

2022

Geographic clusters of objectively measured physical activity and the characteristics of their built environment in a Swiss urban area

Stéphane Joost, Cédric Gubelmann, Marco André Vieira Ruas, Idris Guessous

Introduction ...

PUBLIC LIBRARY SCIENCE2022

Systematic analysis of biomolecular binding reactions using microfluidic systems

Amir Shahein

Transcription factor binding to a single binding site on DNA and its functional consequence in a promoter context are beginning to be relatively well understood. However, binding to clusters of sites has yet to be characterized in depth, and the functional ...

EPFL2022

The standard operating procedure for Airmodus Particle Size Magnifier and nano-Condensation Nucleus Counter

Lubna Dada

Measurements of aerosol particles and clusters smaller than 3 nm in diameter are performed by many groups in order to detect recently formed or emitted nanoparticles and for studying the formation and early growth processes of aerosol particles. The Airmod ...

2022

System and method for transcoding spectral data with task-based optimization via symmetric non-negative matrix factorization

Forrest Simon Webler

A computer-implemented method for reconstructing/recovering high-resolution visible light spectral data at a target resolution d, that comprises obtaining a configuration of a low- resolution multi-channel imaging sensor of resolution p, the configuration ...

2022

The completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: cosmological implications from multitracer BAO analysis with galaxies and voids

Jean-Paul Richard Kneib, Huanyuan Shan, Amélie Tamone, Andrei Variu, Jiaxi Yu, Daniel Felipe Forero Sanchez, Cheng Zhao

We construct cosmic void catalogues with the DIVE void finder upon SDSS BOSS DR12 and eBOSS DR16 galaxy samples with BAO reconstruction, and perform a joint BAO analysis using different types of galaxies and the corresponding voids. The BAO peak is evident ...

OXFORD UNIV PRESS2022

A stellar stream remnant of a globular cluster below the metallicity floor

Pascale Jablonka, Carmela Lardo

Stellar ejecta gradually enrich the gas out of which subsequent stars form, making the least chemically enriched stellar systems direct fossils of structures formed in the early Universe(1). Although a few hundred stars with metal content below 1,000th of ...

NATURE PORTFOLIO2022

Dark matter in galaxy clusters: Parametric strong-lensing approach

Benjamin Emmanuel Nicolas Beauchesne

We present a parametric strong-lensing analysis of three massive galaxy clusters for which Hubble Space Telescope imaging is available, as well as spectroscopy of multiply imaged systems and galaxy cluster members. Our aim is to probe the inner shape of da ...

EDP SCIENCES S A2022

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