Detection of Vibrio cholerae O1 and O139 in environmental waters of rural Bangladesh: a flow-cytometry-based field trial

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Regulation of competence-mediated horizontal gene transfer in the natural habitat of Vibrio cholerae

Melanie Blokesch, Lisa Christina Metzger

The human pathogen Vibrio cholerae is an autochthonous inhabitant of aquatic environments where it often interacts with zooplankton and their chitinous molts. Chitin induces natural competence for transformation in V. cholerae, a key mode of horizontal gen ...

Elsevier2016

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY

Noémie Matthey, Melanie Blokesch, Sandrine Stutzmann, Charles Ulric V Van der Henst, Tiziana Scrignari, Lisa Christina Metzger

Type VI secretion systems (T6SSs) are nanomachines used for interbacterial killing and intoxication of eukaryotes. Although Vibrio cholerae is a model organism for structural studies on T6SSs, the underlying regulatory network is less understood. A recent ...

Elsevier2016

The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11–12th March 2015)

Melanie Blokesch, Frédérique Marie Jeanne Le Roux

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring dur ...

Frontiers Media SA2015

An intracellular replication niche for Vibrio cholerae in the amoeba Acanthamoeba castellanii

Melanie Blokesch, Charles Ulric V Van der Henst, Tiziana Scrignari, Catherine Maclachlan

Vibrio cholerae is a human pathogen and the causative agent of cholera. The persistence of this bacterium in aquatic environments is a key epidemiological concern, as cholera is transmitted through contaminated water. Predatory protists, such as amoebae, a ...

Nature Publishing Group2015

Competence-induced type VI secretion might foster intestinal colonization by Vibrio cholerae

Melanie Blokesch

The human pathogen Vibrio cholerae exhibits two distinct lifestyles: one in the aquatic environment where it often associates with chitinous surfaces and the other as the causative agent of the disease cholera. While much of the research on V. cholerae has ...

Wiley-Blackwell2015

Glucose- but Not Rice-Based Oral Rehydration Therapy Enhances the Production of Virulence Determinants in the Human Pathogen Vibrio cholerae

Flavio Finger, Andrea Rinaldo, Enrico Bertuzzo, Melanie Blokesch, Marino Gatto, Juliane Kühn

Despite major attempts to prevent cholera transmission, millions of people worldwide still must address this devastating disease. Cholera research has so far mainly focused on the causative agent, the bacterium Vibrio cholerae, or on disease treatment, but ...

2014

Cholera in the Lake Kivu region (DRC): Integrating remote sensing and spatially explicit epidemiological modeling

Flavio Finger, Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Marino Gatto, Allyn Christine Knox

Mathematical models of cholera dynamics can not only help in identifying environmental drivers and processes that influence disease transmission, but may also represent valuable tools for the prediction of the epidemiological patterns in time and space as ...

American Geophysical Union2014

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