Serotonin, pregnancy and increased autism prevalence: Is there a link?

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To improve preclinical studies and their translation, patient-derived xenografts (PDXs) are increasingly used. They have human-specific tumor characteristics and reflect intra and inter-tumor heterogeneity. However, the endocrine milieu differs between hum ...

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, g ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

The thalamic reticular nucleus (TRN) is an essential pacemaker within the thalamocortical circuitry that gives rise to non-rapid eye movement (NREM) sleep-related oscillations, such as sleep spindles. Spindle density fluctuations in the infraslow scale def ...

Background Disrupted sense of agency (SoA)-the sense of being the agent of one's own actions-has been demonstrated in patients with functional neurological disorder (FND), and a key area of the corresponding neuronal network is the right temporoparietal ju ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-co ...

The motor learning process entails plastic changes in the brain, especially in brain network reconfigurations. In the current study, we sought to characterize motor learning by determining changes in the coupling behaviour between the brain functional and ...

Very preterm birth (VPT;

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

Functional and structural connectivity alterations in short- and long-range projections have been reported across neurodevelopmental disorders (NDD). Interhemispheric callosal projection neurons (CPN) represent one of the major long-range projections in th ...

Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar d ...

The outstanding information processing capacity of the brain relies on numerous molecular mechanisms. It is an extremely energy-expensive function, which involves specialization and collaboration of different cell types. A common framework to study the com ...

Recent advances in volume electron microscopy (EM) have been driving our thorough understanding of the brain architecture. Volume EM becomes increasingly powerful when cells and their subcellular structures that are imaged in light microscopy are correlate ...

Objective: Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE). ...

An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...

Background The corpus callosum (CC) is a key brain structure. In children with neurodevelopmental delay, we compared standard qualitative radiological assessments with an automatic quantitative tool. Methods We prospectively enrolled 73 child ...

Recent developments in network neuroscience have highlighted the importance of developing techniques for analysing and modelling brain networks. A particularly powerful approach for studying complex neural systems is to formulate generative models that use ...

Which cell types constitute brain circuits is a fundamental question, but establishing the correspondence across cellular data modalities is challenging. Bio-realistic models allow probing cause-and-effect and linking seemingly disparate modalities. Here, ...

The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally modified forms accumulate in pathological inclusions and vary in abundance amo ...

Serotonin, pregnancy and increased autism prevalence: Is there a link?

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Mimicking women’s endocrine milieu in mice for women’s health-related studies

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

The modulation of NREM sleep by corticotropin-releasing hormone through the thalamic reticular nucleus

Non-invasive neuromodulation of the right temporoparietal junction using theta-burst stimulation in functional neurological disorder

White adipose tissue distribution and amount are associated with increased white matter connectivity

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

Brain connectome correlates of short-term motor learning in healthy older subjects

Cortical alterations after very preterm birth and the association with socio-emotional abilities from childhood to early adolescence

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility

Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

Correlative light and volume electron microscopy to study brain development

Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas

Corpus callosum in children with neurodevelopmental delay: MRI standard qualitative assessment versus automatic quantitative analysis

Investigating cognitive ability using action-based models of structural brain networks

Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases