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This paper presents the first search for a cH signal sensitive to the coupling of the charm quark (c) to the Higgs boson (H) in the associated production of at least one charm quark with a Higgs boson decaying to two photons. The results are based on a data set of proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS experiment at the LHC, corresponding to an integrated luminosity of 138 fb−1. Assuming the standard model (SM) rates for all other Higgs boson production processes, the observed (expected) upper limit at 95% confidence level on the cH signal strength is 243 (355) times the SM prediction. Under the same assumption, the observed (expected) allowed interval on the Higgs boson to charm quark coupling modifier, κc, is |κc| < 38.1 (|κc| < 72.5) at 95% confidence level.