Publications related to Effect of freezing of gait and dopaminergic medication in the biomechanics of lower limbs in the gait of patients with Parkinson's disease compared to neurologically healthy

Related publications (19)

GAIT: gait analysis interactive tool a pipeline for automatic detection of gait events across different motor impairments

We introduce an open-access tool capable of automatically extracting the timing of gait events during unconstrained locomotion across different neuromotor impairments. The gait analysis interactive tool is conceived as an assistant for gait assessment stud ...

SPRINGER LONDON LTD2024

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

Johannes Gräff, Giulia Santoni

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify defici ...

WILEY2023

How I became myself after merging with a computer: Does human-machine symbiosis raise human rights issues?

Marcello Ienca

Novel usages of brain stimulation combined with artificially intelligent (AI) systems promise to address a large range of diseases. These new conjoined technologies, such as brain-computer interfaces (BCI), are increasingly used in experimental and clinica ...

ELSEVIER SCIENCE INC2023

CSF tap test in idiopathic normal pressure hydrocephalus: still a necessary prognostic test?

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Maria Giulia Preti

Objective To assess whether gait, neuropsychological, and multimodal MRI parameters predict short-term symptom reversal after cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH). Methods Thirty patients (79.3 +/- 5.9 years ...

SPRINGER HEIDELBERG2022

Toward individualized medicine in stroke-The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Olaf Blanke, Philip Egger, Sylvain Jean-François Harquel, Silvestro Micera, Nathalie Heidi Meyer, Elena Beanato, Valérie Rita Madeleine Zufferey, Gabriel Girard, Julia Brügger, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Estelle Emeline Raffin, Andéol Geoffroy Cadic-Melchior, Traian Popa, Diego de Leon Rodriguez, Martino Bruno Armando Ceroni, Pauline Menoud, Lisa Aïcha Mireille Julie Fleury

Despite recent improvements, complete motor recovery occurs in < 15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge concerning the preci ...

FRONTIERS MEDIA SA2022

Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy

Hilal Lashuel, Melek Firat Altay

Aggregated alpha-synuclein (alpha-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA ...

MDPI2022

Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease

Hilal Lashuel

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, alpha-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an econom ...

NATURE RESEARCH2021

Personalizable computational models of electrical spinal cord stimulation to restore function after neurological disorders

Andreas Rowald

Spinal Cord Injury (SCI) disrupts the communication between the brain and spinal circuits below the lesion, leading to a plethora of neurological impairments, including the loss of motor function. At present, the only medical practices to enhance recovery ...

EPFL2021

Adaptive, personalized closed-loop therapy for Parkinson's disease: biochemical, neurophysiological, and wearable sensing systems

Eduardo Martin Moraud

Introduction Motor complication management is one of the main unmet needs in Parkinson's disease patients. Areas covered Among the most promising emerging approaches for handling motor complications in Parkinson's disease, adaptive deep brain stimulation s ...

TAYLOR & FRANCIS LTD2021

Spatiotemporal Maps of Proprioceptive Inputs to the Cervical Spinal Cord During Three-Dimensional Reaching and Grasping

Auke Ijspeert, Pierre Charles Marie Kibleur, Marco Capogrosso, Nathan Antoine Greiner, Shravan Tata Ramalingasetty

Proprioceptive feedback is a critical component of voluntary movement planning and execution. Neuroprosthetic technologies aiming at restoring movement must interact with it to restore accurate motor control. Optimization and design of such technologies de ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

Investigation of alpha-synuclein post-translational modifications in idiopathic Parkinson's disease and multiple system atrophy

Hilal Lashuel

WILEY2019

Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity

Bénédicte Marie Maréchal

Background and Purpose- Poststroke fatigue affects a large proportion of stroke survivors and is associated with a poor quality of life. In a recent trial, modafinil was shown to be an effective agent in reducing poststroke fatigue; however, not all patien ...

LIPPINCOTT WILLIAMS & WILKINS2019

Assessment of the lower limb soft tissue artefact at marker-cluster level with a high-density marker set during walking

Kamiar Aminian, Arnaud Barré

The estimation of joint kinematics from skin markers is hindered by the soft tissue artefact (STA), a well-known phenomenon although not fully characterized. While most assessments of the STA have been performed based on the individual skin markers displac ...

Elsevier2017

Implantable and wearable measurement system for smart knee prosthesis

Kamiar Aminian, Philippe Renaud, David Forchelet, Arash Arami

In this work we present the implantable and wearable measurement system developed for smart knee prostheses monitoring. The kinematic measurement system contains three anisotropic magnetoresistive sensors embedded into the polyethylene part of the prosthes ...

IEEE2014

The effects on biomechanics of walking and balance recovery in a novel pelvis exoskeleton during zero-torque control

Silvestro Micera

Fall-related accidents are among the most serious concerns in elderly people, amputees and subjects with neurological disorders. The aim of this paper was to investigate the behaviour of healthy subjects wearing a novel light-weight pelvis exoskeleton cont ...

Cambridge University Press2014

The role of S129 phosphorylation in regulating the cellular properties and secretion of alpha-synuclein : implication for alpha-synuclein function in health and disease

Martial Mbefo Kamdem

EPFL2014

Classification of stance and swing gait states during treadmill walking from non-invasive scalp electroencephalographic (EEG) signals

Sara Grassi Pauletti, Pierre-André Farine

In Contreras-Vidal and colleagues have shown the feasibility of inferring the linear and angular kinematics of treadmill walking from scalp EEG. Here, we apply a discrete approach to the same problem of decoding the human gait. By reducing the gait process ...

Springer2013

Modular methodology to design high precision parallel robots and application to a 5-Degree of Freedom flexure-based manipulator

Reymond Clavel, Murielle Richard

This paper presents a novel modular methodology to design ultra-high precision parallel robots. It chiefly aims at significantly decreasing both the complexity of their synthesis and their development time. This approach can be compared to a robotic Lego®, ...

2012

Design and Calibration of Ultra-high-precision Industrial Robots

Reymond Clavel, Murielle Richard, Emanuele Lubrano

In this paper we present the key phases to design and calibrate ultra-high-precision industrial robots (i.e. submicrometric precision robots). The first part of our study will cover the robot design aspects, from the choice of the kinematics with the help ...

Institute of Electrical and Electronics Engineers2012