Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

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Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

Unraveling the neuronal mechanisms of fear learning might allow neuroscientists to make links between a learned behavior and the underlying plasticity at specific synaptic connections. In fear learning, an innocuous sensory event such as a tone (called the ...

The thalamic reticular nucleus (TRN) neurons, projecting across the external medullary lamina, have long been considered to be the only significant source of inhibition of the somatosensory ventral posterior (VP) nuclei of the thalamus. Here we report for ...

The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic co ...

Neurons are endowed with dendrites: tree-like structures that collect and transform inputs. These arborizations are believed to substantially enhance the computational repertoire of neurons. While it has long been known that dendrites are not iso-potential ...

Synaptic plasticity, the putative basis of learning and memory formation, manifests in various forms and across different timescales. Here we show that the interaction of Hebbian homosynaptic plasticity with rapid non-Hebbian heterosynaptic plasticity is, ...

During the formation of neuronal circuits, axon pathfinding decisions specify the location of synapses on the correct brain side and in correct target areas. We investigated a possible link between axon midline crossing and the subsequent development of ou ...

There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of ...

Simultaneous tracking of many thousands of individual particles in live cells is possible now with the advent of high-density superresolution imaging methods. We present an approach to extract local biophysical properties of cell-particle interaction from ...

Magnetic resonance spectroscopy (MRS) allows measurement of neurotransmitter concentrations within a region of interest in the brain. Inter-individual variation in MRS-measured GABA levels have been related to variation in task performance in a number of r ...

Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we presen ...

Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

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Principles of Network Plasticity in Neocortical Microcircuits

Fear Learning: An Evolving Picture for Plasticity at Synaptic Afferents to the Amygdala

Morphology, physiology and synaptic connectivity of local interneurons in the mouse somatosensory thalamus

Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins

Using the Green's function to simplify and understand dendrites

Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks

Robo3-Driven Axon Midline Crossing Conditions Functional Maturation of a Large Commissural Synapse

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Heterogeneity of AMPA receptor trafficking and molecular interactions revealed by superresolution analysis of live cell imaging

Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex

Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures