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The asymmetric synthesis of long chain di- and tri-amino polyols is reported. The developed methodology is based on the functionalization of 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives that allows the selective introduction of amine moieties on defined positions of polyketide fragments. The versatile strategy disclosed here requires few purification steps and may generate a large panel of stereoisomers.
Jieping Zhu, Qian Wang, Anne-Clémence Corminboeuf, Simone Gallarati, Takuji Fujii
Phillip Gulliver Dominic Greenwood