Publication

Functionalization of adhesion sites for cell attachment on a silicon microsystem

2012
Student Projects

Abstract

Mesenchymal Stem Cells (MSC) are multipotent adult stem cells that are predominantly obtained from the bone marrow. MSC have a high ability to differentiate into a multitude of cell types that are very attractive for tissue engineering. To study the effects of mechanical strain on this kind of cells, we have developed a silicon microsystem (see the photograph below). The main objective of this semester project will be to create functionalized adhesion sites for fibroblasts and MSC attachment on a silicon device. First, the student will have to find and test different methods which could be used to promote single-cell adhesion on silicon. Then, he will have to adapt this method to our system and perform preliminary tests with fibroblasts.

Official source

https://infoscience.epfl.ch/entities/publication/3aaa1453-e65a-41f8-a585-399c0e3458e7

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2012
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/3aaa1453-e65a-41f8-a585-399c0e3458e7

About this result

Related concepts (32)

Stem cell

In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type.

Adult stem cell

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells. Scientific interest in adult stem cells is centered around two main characteristics.

Mesenchymal stem cell

Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).

Related publications (14)

Functionalization of adhesion sites for cell attachment on a silicon microsystem

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