Publications related to GlobalBioIm: A Unifying Computational Framework for Solving Inverse Problems

Related publications (33)

Exploiting Covalent Chemical Labeling with Self-Labeling Proteins

The visualization and manipulation of proteins in live cells are critical for studying complex biological processes. Self-labeling proteins do so by enabling the specific and covalent attachment of synthetic probes, offering unprecedented flexibility in th ...

Annual Reviews2025

Bioanode engineering for living solar cells

Charlotte Elisabeth Marie Roullier

Whole-cell biophotovoltaic (BPV) devices leverage photoautotrophic microorganisms like cyanobacteria to convert sunlight and water into bioelectricity. They are capable of growing on sequestered carbon dioxide (CO2), eliminating the need to add exogenous o ...

EPFL2025

Mesh-based topology, shape and sizing optimization of ribbed plates

Ahmad Abdulrahman Ahmad Majdouba

In this paper, we present a new parameterization and optimization procedure for minimizing the weight of ribbed plates. The primary goal is to reduce embodied CO2 in concrete floors as part of the effort to diminish the carbon footprint of the construction ...

Springer2024

Estimation of the bar stress based on crack width measurements in reinforced concrete structures

Aurelio Muttoni, Enrique Corres Sojo

Estimating the stress of reinforcing bars and its variations in service conditions can be useful to determine the reserve capacity of structures or to assess the risk of fatigue in the reinforcement. This paper investigates the use crack width measurements ...

Ernst & Sohn2024

Compact and effective photon-resolved image scanning microscope

Giorgio Tortarolo

Fluorescence confocal laser-scanning microscopy (LSM) is one of the most popular tools for life science research. This popularity is expected to grow thanks to single-photon array detectors tailored for LSM. These detectors offer unique single-photon spati ...

Spie-Soc Photo-Optical Instrumentation Engineers2024

Surface passivation and functionalisation for mass photometry

Laila Abdelaziz Abdelmoniem Elfeky, Suliana Manley, Jenny Sülzle

Interferometric scattering (iSCAT) microscopy enables the label-free observation of biomolecules. Consequently, single-particle imaging and tracking with the iSCAT-based method known as mass photometry (MP) is a growing area of study. However, establishing ...

Wiley2024

A concrete answer for circular construction: three prototypes reusing saw-cut elements

Corentin Jean Dominique Fivet, Maléna Bastien Masse, Célia Marine Küpfer

Existing concrete buildings should be retained for as long as possible to reduce the environmental burden of demolition and new construction. However, when urban pressure makes demolition unavoidable, salvaging and reusing concrete elements elsewhere in ne ...

2024

Reusability assessment of reinforced concrete components prior to deconstruction from obsolete buildings

Corentin Jean Dominique Fivet, Maléna Bastien Masse, Julie Rachel Devènes

A large part of building demolitions is motivated by purely socio-economic reasons. Hence, about-to-be-demolished structures, commonly made of reinforced concrete, very often present no or little degradation. When adaptive reuse of the entire building is n ...

2024

Revealing chromatin-specific functions of histone deacylases

Beat Fierz, Carlos Moreno Yruela

Histone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in v ...

2024

Contributions to rebar-to-concrete interaction and its structural implications for design and monitoring applications

Enrique Corres Sojo

Bond between reinforcing bars and concrete has been the focus of extensive research over the last century. This is well-justified as the functioning of reinforced concrete intimately depends on the interaction between rebar and concrete, as for example cra ...

EPFL2024

Fluorescence microscopy: A statistics-optics perspective

Aleksandra Radenovic

Fundamental properties of light unavoidably impose features on images collected using fluorescence microscopes. Accounting for these features is often critical in quantitatively interpreting microscopy images, especially those gathering information at scal ...

Amer Physical Soc2024

Structural component reuse of precast and cast-in-place reinforced concrete in architecture since the late 1960s in Europe

Corentin Jean Dominique Fivet, Célia Marine Küpfer

The reuse of concrete pieces salvaged from structures undergoing transformation or demolition into new architectural projects has gained a sudden and visible interest over the past five years. However, the practice of reusing concrete pieces in new structu ...

vdf Hochschulverlag AG2024

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

SPIE Society of Photo-optical Instrumentation Engineers2024

Experimental and analytical investigation of shear-reinforced concrete and dowel action

Marko Pejatovic

Codes of practice can be overly conservative, particularly for the shear resistance of reinforced concrete beams with shear reinforcement when large loads act close to supports. This thesis addresses the topic by proposing a refined design approach based o ...

EPFL2024

Experimental investigation of dowel action in reinforcing bars using refined measurements

Aurelio Muttoni, Marko Pejatovic

In typical reinforced concrete design, reinforcement is designed to carry axial forces, but it can also resist transversal forces by dowel action. This is usually neglected for simplicity's sake in the design phase, but it can be accounted for either expli ...

Ernst & Sohn2024

The time-domain Cartesian multipole expansion of electromagnetic fields

Emanuela Radici, Farhad Rachidi-Haeri, Marcos Rubinstein, Nicolas Mora Parra, Elias Per Joachim Le Boudec

Time-domain solutions of Maxwell’s equations in homogeneous and isotropic media are paramount to studying transient or broadband phenomena. However, analytical solutions are generally unavailable for practical applications, while numerical solutions are co ...

Nature Publishing Group2024

Influence of model uncertainty and long term deformations in action effects calculation in reinforced concrete structures

Xhemsi Malja

Most codes of practice adopt a semi probabilistic design approach for the dimensioning and assessment of structures. Accordingly, structural safety is ensured by performing limit state verifications using design values determined with adequately calibrated ...

EPFL2024

FLO:RE – A new floor system made of reused reinforced concrete and steel elements

Corentin Jean Dominique Fivet, Numa Joy Bertola, Maléna Bastien Masse, Célia Marine Küpfer

Carefully extracting reinforced concrete (RC) elements from soon-to-be demolished structures and reusing them as load-bearing components is an emerging circular low-carbon alternative to building new structures. As floor construction typically accounts for ...

IABSE2024

The multimodality cell segmentation challenge: toward universal solutions

Maxime Emmanuel Scheder, Jun Ma, Sahand Jamal Rahi, Xin Yang, Vojislav Gligorovski, Marco Labagnara

Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to specify hyper-parameters in different experimen ...

Nature Publishing Group2024

Model uncertainties in action effects and load bearing capacity calculation in statically indeterminate reinforced concrete structures

Aurelio Muttoni, Alain Nussbaumer, Xhemsi Malja

For the dimensioning and assessment of structures, it is common practice to compare action effects with sectional resistances. Extensive studies have been performed to quantify the model uncertainty on the resistance side. However, for statically indetermi ...

Ernst & Sohn2024