Publication

Comparaison du stimulus mécanique appliqué in vivo sur un tibia de souris entre une souris C57BL6 wild type et une souris C57BL6 betaArrestin2 KO

Dominique Pioletti
2008
Student Projects

Abstract

Une étude in vivo de stimulation mécanique de tibia de souris est en cours au LBO actuellement. Nous comparons la réponse métabolique des souris C57BL6 wild type ou betaArrestin2 KO. betaArrestin2 est une molécule associée à l'internalisation de la Parathyroid Hormone. Les souris betaArrestin2 KO développent une ossature plus petite que les wild type. C'est pourquoi il est nécessaire de calibrer la force mécanique appliquée sur les tibias en fonction de la souche génétique pour que la contrainte ressentie soit la même. Le projet consistera a comparer les déformations réelles dans les deux types de souris. Un modèle numérique existe aussi afin de valider les résultats expérimentaux.

Official source

https://infoscience.epfl.ch/entities/publication/3975c91a-aac7-4d16-a15d-abebc4eb8f07

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Dominique Pioletti
2008
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/3975c91a-aac7-4d16-a15d-abebc4eb8f07

About this result

Related concepts (2)

G protein-coupled receptor

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. They are coupled with G proteins.

Κ-opioid receptor

The κ-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene. The KOR is coupled to the G protein Gi/G0 and is one of four related receptors that bind opioid-like compounds in the brain and are responsible for mediating the effects of these compounds. These effects include altering nociception, consciousness, motor control, and mood. Dysregulation of this receptor system has been implicated in alcohol and drug addiction.