Publication

Intramolecular Arylation of Tertiary Enamides through Pd(OAc)2-Catalyzed Dehydrogenative Cross-Coupling Reaction: Construction of Fused N-Heterocyclic Scaffolds and Synthesis of Isoindolobenzazepine Alkaloids

Jieping Zhu, Shuo Tong
2019
Journal Articles

Abstract

Pd(OAc)2-catalyzed intramolecular dehydrogenative cross-coupling reaction between tertiary enamides, which were derived from the condensation of 2-arylethylamines and methyl o-acetylbenzoate, and arenes enabled synthesis of 7,8-dihydro-5H-benzo[4,5]azepino[2,1-a]-isoindol-5-one derivatives under mild conditions. The synthetic method was applied in the total synthesis of aporhoeadane alkaloids palmanine, lennoxamine, and chilenamine in only three or four steps.

Official source

https://infoscience.epfl.ch/entities/publication/391cc638-976e-4ca5-81dc-4e7ce595b3fd

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Jieping Zhu, Shuo Tong
2019
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/391cc638-976e-4ca5-81dc-4e7ce595b3fd

About this result

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